Observation of combination anesthesia with low-dose ketamine and mid-dose pentobarbital for open heart surgeryin juvenile pigs
10.3969/j.issn.1001-6821.2010.01.013
- VernacularTitle:观察小剂量氯胺酮与中剂量戊巴比妥对幼猪心内直视手术的复合麻醉效果
- Author:
De-Bin LIU
1
;
Yan-Bin SHAO
;
Xiu-Zhu LUAN
;
Chao-Xiang SHUI
;
Zhen-Ya ZHANG
;
Qing-Yu WU
Author Information
1. 兰州大学第一医院
- Keywords:
combination anesthesia;
open heart surgery;
ketamine
- From:
The Chinese Journal of Clinical Pharmacology
2010;26(1):49-52
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate combination anesthesia with low-dose ketamine and mid-dose pentobarbital for open heart surgery in ju-venile pigs.Methods Thirty experimental juvenile pigs received ket-amine(3 mg·kg~(-1))and pentobarbital(20 mg·kg~(-1))intramuscularly for induction and intubation,then were given ketamine(5 mg·kg~(-1)·h~(-1)),pentobarbital(6-8 mg·kg~(-1)·h~(-1)),midazolam(0.1-0.2mg kg~(-1)·h~(-1))and pipecuronium(0.1 mg·kg~(-1)·h~(-1))intravenously for maintenance.The infusion of pentobarbital was withdrawn after car-diopulmonary bypass started.During the experimental treatment,vital signs were monitored;artery gas analysis and hemodynamie parameters were recorded.Results Twenty-eight juvenile pigs got stable hemody-namic parameters in the perioperative period.The time of anesthetic in-duction and maintenance is(9±2)and(179±15)min,respectively.The respiratory and cardiac arrest rates were 6.7% in induction and 3.3% in maintenance.respectively.Two cases got respiratory and cardi-ac arrest.on in induction and the OtIler after extubation.In addition,class I anesthetic effectiveness was achieved 73.3% in induction and 80.0% in maintenance,respectively.Conclusion This study demon-strated that lOW-dose ketamine combined with mid-dose pentobarbihal has little inhibition on respiration and circulation.The combination can achieve both hypnosis and analgesia effects with good surgical anesthetic effectiveness in juvenile pigs with open heart surgery.
