Pharmacokinetics of ibuprefen and pseudo ephedrine with chlorpheniramine suspension after single and multiple doses in healthy volunteers
10.3969/j.issn.1001-6821.2010.01.008
- VernacularTitle:单剂量和多剂量口服布洛伪麻那敏干混悬剂在健康人体的药代动力学
- Author:
Min SONG
1
;
Hong-Yi TAN
;
Zhi-Rong TAN
;
Chang LIU
;
Li YANG
;
Hong XIANG
;
Zhi-Jun HUANG
;
Gui-Xiang ZHANG
;
Guo-Ping YANG
Author Information
1. 中南大学
- Keywords:
ibuprofen;
pseudo ephedrine;
chlorpheniramine;
pharmaco-kinetics;
HPLC;
HPLC-MS-MS
- From:
The Chinese Journal of Clinical Pharmacology
2010;26(1):28-32,36
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the pharmacokinetics profiles of ibupro-fen and pseudo ephedrine with chlorpheniramine suspension after single and multiple dosing in healthy volunteers.Methods Three single and one multiple oral doses of ibuprofen and pseudo ephedrine with chlorphe-niramine suspension were given to healthy volunteers respectively.Ibu-profen concentrations in plasma were determined by HPLC-UV method.Pseudo ephedrine and chlorpheniramine concentrations in plasma were determined by HPLC-MS-MS method.The pharmacokinetic parameters were obtained with statistical analysis by DAS Ver 2.0.Results The main pharmacokinetic parameters of 3 single doses(ibuprofen:200,400,600 mg pseudo ephedrine:30,60,90 mg;chlorpheniramine:2,4,6 mg)and multiple dose(ibuprofe,pseudo ephedrine and chlorphe-niramine 200,30,2 mg,respectively)shown that the concentration-time curves of ibuprofen,pseudo ephedrine and chlorpheniramine were described by one-compartment open model and physiological disposi-tions were assumed by linear kinetics characteristics.Conclusion In multiple dosing study,physiological dispositions of ibuprofen,pseudo e-phedrine and chlorpheniramine all existed no induction and inhibition of drug enzyme phenomenon.
