Effects of melatonin on the sleep disorder in the elderly
10.3969/j.issn.1001-6821.2010.01.003
- VernacularTitle:褪黑素对老年人睡眠障碍的调节作用
- Author:
Jing-Yu NIU
1
;
Shu-Ying CHANG
;
Jun-Tian ZHANG
;
He GAO
;
Jing-Gui HE
;
Yu-Hong HE
;
Bao-He ZHANG
;
Zhi-Ping WU
;
Xiao-Luo MENG
;
Hu-Feng YU
;
Lu-Ning WANG
Author Information
1. 解放军空军总医院
- Keywords:
melatonin;
sleep disorder;
sub-health
- From:
The Chinese Journal of Clinical Pharmacology
2010;26(1):9-12
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence of melatonin(MT)on the sleep of anxiety and depression in elderly with sleep disorder and elderly patients with non-acute cardiac and/or cerebral vascular diseases.Methods The effect of melatonin on sleep Was assessed in a multi-centers,randomized,double blinded and placebo paralleled comparison clinical study.Two hundreds twenty-four participants aged over 60 years old were cases in sub-health state or with non-acute cardiac and/or cerebral Vascular diseases.They were randomly seperated into two groups,and received ether MT(3-6 mg once daily)or starch for 6 months.AU of the subjects were assessed with Pittsburgh sleep quality index(PSQI).Results The participants'total score of PSQI decreased significantly after 1-6 months use of melatonin,representing the remarkable improvement in sleep quality.After the first month.69.3% showed improvement in sleep quality;through the second,third,fourth,five month,the improvement in total score had been going on,and was significantly better in melatonin group than the control group.At the end of the six month,the sleep quality showed the best improvement,with a 91.2% effective rate.Conclusion Melatonin has an remarkable physical effect of improving the sleep quality in old people.
