Dosage regimen of cefaclor based on pharmacokinetic-pharmacodynamic model
10.3969/j.issn.1001-6821.2009.06.013
- VernacularTitle:基于PK/PD模型的头孢克洛给药方案
- Author:
Jun-Xian YU
1
;
Jian-Ping LUO
;
Li-Min SHI
;
Yin-Di ZHANG
;
Shan LI
;
Man-Li WANG
;
Chun-Xiu YANG
;
Ru-Long WANG
Author Information
1. 首都医科大学附属北京友谊医院
- Keywords:
cefaclor;
pharmacokinetic-pharmacodynamic model;
HPLC
- From:
The Chinese Journal of Clinical Pharmacology
2009;25(6):530-533
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study dosage regimen of cefaclor based on pharmacokinetic-pharmacodynamic model by gastrointestinal route. Methods The study was conducted in ten healthy vounteers. After receiving a single dose of 500 mg cefaclor dispersible tablets on the three dosage regimen (500 mg three times a day;500 mg four times a day;500 mg five times a day). Blood drug concentration were determined by HPLC-UV and the pharmacokinetic parameters were calculated by CAPP program. The pharmacodynamic parameters were minimal inhibitory concentration ( MIC_(90) ) of sensitive bacteria The pharmacokinetic and pharmacodynamic parameters were simulated by CAPP program for T > MIC_(90) value, and reasonable dosage regimen was calculated. Results The PK/PD model established by CAPP suggest that the value of T > MIC_(90) of three dosage regimen was 25. 5% , 34. 0% and 42.5%, respectively. Conclusion To achieve the ideal value 35%-55% of T > MIC_(90) and more effectiveness, cefaclor may be taken orally 500 mg four times a day.
