In vitro effects of Danhong injection on electrocardiogram and proarrhythmias in the rabbit left ventricular wedge preparation
10.3969/j.issn.1001-6821.2009.06.008
- VernacularTitle:丹红注射液对兔离体左心室心电图及致心律失常作用
- Author:
Xiao-Lin XUE
1
;
Teng-Xian LIU
;
Lin YANG
;
Dong-Qi WANG
;
Chang-Cong CUI
;
Can-Xin YAN
Author Information
1. 西安交通大学医学院附属第一医院
- Keywords:
Danhong injection;
rabbit left ventricular wedge preparation;
QRS duration;
QT interval;
Tp-e interval
- From:
The Chinese Journal of Clinical Pharmacology
2009;25(6):509-513
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of Danhong injection on electrical activity of rabbit heart. Methods The arterially perfused rabbits left ventricular preparations were used in the experiments. The preparations were stimulated at basic cycle lengths (BCL) of 1000 ms for 1 h before the experiment started. The Danhong injection was set in trial group. Captopril was set as a negative control group and sparfloxacin as a positive control group. The transmural ECG was recorded and QRS duration, QT interval, Tp-e interval and Tp-e/QT ratio were measured. Results Donghong injection had no significant effect on QRS duration in the concentration ranges tested. At concentrations of 20 mL · L~(-1) and 60 mL · L~(-1), Danhong injection could produce a small but statistically significant QT prolongation. However, this effect is comparable to the negative control drug captopril. Both Danhong injection and captopril had no significant effect on Tp-e and Tp-e/QT ratio, also, which did not cause any proarrhythmic events in any preparation at any concentration. Conclusion Danghong injection possesses no significant risk of TdP and other proarrhythmias like ventricular tachycardia in the concentration less than or on the verge of 30 times of free therapeutic plasma C_(max).
