Antibacterial activity of levofloxacin combined with fosfomycin against Staphylococcus aureus
10.3969/j.issn.1001-6821.2009.06.007
- VernacularTitle:左氧氟沙星与磷霉素联用对30株金黄色葡萄球菌的抗菌活性
- Author:
Xiu-Jie SONG
1
;
You-Ning LIU
;
Hong-Mei JU
Author Information
1. 解放军总医院
- Keywords:
Staphylococcus aureus;
levofloxacin;
fosfomycin combination therapy
- From:
The Chinese Journal of Clinical Pharmacology
2009;25(6):505-508
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the in vitro effects of levofloxacin combined with fosfomycin upon 30 strains of clinical isolates of Staphylo-coccus aureus (15 strains methicillin resistant and 15 strains methicillin sensitive Staphylococcus aureus ) . Methods A checkerboard method that adhered to the recommendations of the National Committee for Clinical Laboratory Standards was applied to assess the synergism effect between levofloxacin and fosfomycin. The FIC index was calculated according to the results. Results The MIC_(50) was reduced significantly for the combination of levofloxacin plus fosfomycin against Staphylococcus aureus. The FIC indexes of methicillin sensitive Staphylococcus aureus (MSSA ) less than 0. 5, from 0. 5 to 1, from 1 to 2, more than 2 were 36. 4% ,63. 6% ,0,0 respectively. The FIC indexes of methicillin resistant Staphylococcus aureus ( MRSA) less than 0. 5 ,from 0. 5 to 1 ,from 1 to 2,more than 2 were 81. 8% , 18. 2% ,0,0, respectively. Conclusion In vitro the combination of subinhibitory concentration of levofloxacin and fosfomycin presented synergistic and additive effect There were no antagonism.
