Pharmacokinetics of sodium aescinate for injection in healthy volunteers
10.3969/j.issn.1001-6821.2009.06.005
- VernacularTitle:注射用七叶皂苷钠在健康人体的药代动力学
- Author:
Xia ZHAO
1
;
Yan LIANG
;
Min LU
;
Shuo-Han TIAN
;
Hui-Lin ZHANG
;
Jing-Kai GU
;
Yi-Min CUI
Author Information
1. 北京大学第一医院
- Keywords:
sodium aescinate for injection;
pharmacokinetics
- From:
The Chinese Journal of Clinical Pharmacology
2009;25(6):498-500
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the pharmacokinetics of sodium aesci-nate after intravenous infusion in Chinese healthy volunteers. Methods Sodium aescinate for injection were given to 9 healthy volunteers of a single dose of 10 mg, the concentrations of aescinate in human plasma and urine were determined by HPLC-MS/MS, the main pharmacokinetic parameters were calculated with WinNonlin 5. 0. Results The main pharmacokinetic parameters of A ingredient of aescinate and B ingredient of aescinate were as follows: C_(max) were ( 283. 00 ± 70. 53 ), (206. 33 ± 57.20) ng · mL~(-1); AUC_(0-t) were (1008.05 ±396.49), (638.96 ± 259. 48) ng · h · mL~(-1);t_(1/2) were(3. 72 ±0. 44), (3.57 ±0.48) h;V_z were (19. 39 ±7. 05), (23.82 ±11.43) L;CL were (3. 66 ± 1. 36), (4. 55 ± 1. 86) L · h~(-1) ;36 hour accumulative urine excretion rates were (4. 91 ± 1. 38) % , (2. 80 ± 0. 71 ) % , respectively. Conclusion The disposing process of A ingredient of aescinate and B ingredient of aescinate in healthy subjects were resemble, the elimination half life was about 3. 6 h, the accumulative urine excretion rate was low.
