Study on pharmacological effect of Manshenling granules on chronic renal failure in rats
10.3969/j.issn.1001-6821.2009.04.009
- VernacularTitle:慢肾灵颗粒剂治疗大鼠慢性肾功能衰竭的药效学研究
- Author:
Xiu-Zhen ZHOU
1
;
Jian-Hua LIU
;
Ji-Mei SUN
;
Yong LIU
Author Information
1. 中国医科大学附属盛京医院
- Keywords:
glomenrular sclerosis;
chronic renal failure;
Manshenling granules
- From:
The Chinese Journal of Clinical Pharmacology
2009;25(4):326-328
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the pharmacological effect of Mansh-enling granules on chronic renal failure (CRF) induced by daunorubicin in rats. Methods CRF was induced with injecting daunorubicin repeat-edly after uninephrectomy. In addition normal group, the CRF Wistar rats were randomly divided in to 5 groups: model group, control group (Niaoduqing granules 2.3 g·kg-1 ), and large, middle, small dose ( Manshenling granules 2.70、1.35,0. 68 g·kg-1) test groups. The ne-phroprotective effects of Manshenling granules was investigated. Results In large and middle groups, serum creatinine, BUN and urinary protein were significantly decreased than those in model group. Glomerul- cell prolifera-tion and glomerular sclerosis level were slighter than in model group. Con-clusion Manshenling granules can reduce the injury of renal in CRF rats.
