Research progress of hyperhemolytic syndrome after transfusion
10.13303/j.cjbt.issn.1004-549x.2025.02.022
- VernacularTitle:输血后超溶血综合征研究进展
- Author:
Ziyi HE
1
Author Information
1. Dongguan Blood Center, Dongguan 523000, China
- Publication Type:Journal Article
- Keywords:
hyperhemolytic syndrome;
bystander hemolysis;
blood transfusion;
acute hemolytic transfusion reaction;
delayed hemolytic transfusion reaction
- From:
Chinese Journal of Blood Transfusion
2025;38(2):291-296
- CountryChina
- Language:Chinese
-
Abstract:
Hemolytic transfusion reactions after transfusion include acute hemolytic transfusion reaction and delayed hemolytic transfusion reaction. However, clinically, it is observed that after transfusion, the hemoglobin (Hb) level not only fails to increase but is actually lower than before transfusion. Excluding factors such as bleeding from trauma or surgery and dilution from large volume infusions, this indicates that the recipient's red blood cells are undergoing hemolysis, a phenomenon known as hyperhemolysis syndrome. The mechanism of hyperhemolytic syndrome is not completely clear, there are few reports in domestic literature, and clinical understanding is insufficient, which is easy to miss and misdiagnosis. This paper summarizes seven possible mechanisms of hyperhemolytic syndrome and reviews the concept, clinical features, pathogenesis and clinical treatment of hyperhemolytic syndrome.
