Eficacy and safety of washed red blood cells and white suspended red blood cells in the treatment of autoimmune hemolytic anemia: a meta-analysis
10.13303/j.cjbt.issn.1004-549x.2025.02.021
- VernacularTitle:洗涤红细胞和去白悬浮红细胞治疗自身免疫性溶血性贫血疗效和安全性的Meta分析
- Author:
Wenda FU
1
;
Hua WEI
1
;
Dan LI
1
;
Longfei YANG
1
Author Information
1. Department of Blood Transfusion, the Second Affiliated Hospital of Air Force Medical University, Xi’an 710038, China
- Publication Type:Journal Article
- Keywords:
washed red blood cells;
white suspended red blood cells;
autoimmune hemolytic anemia;
meta-analysis
- From:
Chinese Journal of Blood Transfusion
2025;38(2):284-290
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To systematically evaluate the therapeutic effect of washed red blood cells and white suspended red blood cells on patients with autoimmune hemolytic anemia, and to provide reference for their clinical treatment. [Methods] CNKI, Wanfang, VIP, PubMed, Embase, Cochrane Library and other databases from the establishment of the database to August 2024 were searched, including the randomized controlled trials of washed red blood cells and white suspended red blood cells in the treatment of autoimmune hemolytic anemia that met the requirements. After literature screening, data extraction and quality evaluation, meta-analysis was performed using Review manager 5.3 software and Stata 15.1 software to analyze the therapeutic effect of blood transfusion in the primary outcome, hematological indicators (Hb, Ret, RBC, and TBIL) of the two groups after blood transfusion and the occurrence of adverse blood transfusion reactions. [Results] After screening, 10 literatures meeting the criteria were retrieved, and a total of 753 patients with autoimmune hemolytic anemia were treated with washed red blood cell infusion in the observation group and white suspended red blood cell infusion in the control group. Meta-analysis suggested that there was no significant difference in the therapeutic effect of transfusion between patients who received washed red cells and those received white suspended red cells[SMD=1.16, 95%CI (0.87, 1.54), P>0.05]. The hematological indexes of the two groups after transfusion (Hb [SMD=0.04, 95%CI (-0.14, 0.22), P>0.05]、Ret[SMD=-0.15, 95%CI (-0.34, 0.03), P>0.05]、RBC[SMD=0.08, 95%CI (-0.10, 0.26), P>0.05] and TBIL [SMD=-0.02, 95%CI (-0.18, 0.15), P>0.05]) and the incidence of transfusion adverse reactions[SMD=0.8, 95%CI (0.47, 1.39), P>0.05] were not significantly different. [Conclusion] Based on the current study, the efficacy and safety of infusion of washed red blood cells and white suspended red blood cells are comparable in patients with autoimmune hemolytic anemia. However, considering the simple preparation process of washed red blood cells and the low price, infusion of washed red blood cells is recommended for patients with autoimmune hemolytic anemia.
