Bacterial contamination of platelets apheresis: a single-center retrospective analysis
10.13303/j.cjbt.issn.1004-549x.2025.02.012
- VernacularTitle:单采血小板细菌污染的单中心回顾性分析
- Author:
Yuanyuan LUO
1
;
Chunya MA
1
;
Lihui FU
1
;
Zeshan WANG
1
;
Yang YU
1
Author Information
1. Department of Transfusion Medicine, The First Medical Center of PLA General Hospital, Beijing 100853, China
- Publication Type:Journal Article
- Keywords:
transfusion-transmitted bacterial infection;
platelets apheresis;
bacterial contamination;
diagnostic rate
- From:
Chinese Journal of Blood Transfusion
2025;38(2):233-237
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To evaluate the risk of bacterial contamination of platelets apheresis and improve the clinical diagnosis rate of transfusion-transmitted bacterial infections. [Methods] A retrospective analysis was conducted on 11 cases involving bacterial contamination detected in apheresis platelets during quality inspections at our center from 2021 to 2023, as well as cases of transfusion-transmitted bacterial infection (TTBI) caused by platelet transfusion. The return of positive platelet bacteria test results and clinical transfusion adverse reactions were statistically analyzed. [Results] There were 9 donors with bacteria-contaminated platelets, of which 3 were reported as clinical transfusion reaction, 4 were detected by quality sampling, and 2 were identified by appearance detection before transfusion. The bacterial contamination rate of platelets was about 0.08% (9/10 762). The contaminated platelets were involved in 11 cases of TTBI, with an incidence of TTBI of approximately 0.05% (11/21 916). Only 3 cases of transfusion reactions were clinically reported, while the rest were case tracking with positive results of platelet bacterial test from quality sampling. The clinical return rate of TTBI was 27.27% (3/11), with an average reporting time of 8.12 hours after the occurrence of transfusion reactions. The majority of the contaminated platelets were detected at the end stage of storage, with 55.56% (5/9) of platelets collected on the 4th day after collection. Partial contaminated platelets were identified through quality sampling, with a positive rate of 2.78% (4/144). [Conclusion] The platelet bacterial contamination rate is high, but with low clinical return rate. It is recommended to conduct routine platelet bacterial monitoring and improve clinical diagnostic level.
