Role of autophagy in treatment of paracetamol-induced liver injury
- VernacularTitle:自噬在对乙酰氨基酚诱导肝损伤中的作用
- Author:
Guojing XING
1
;
Lifei WANG
1
;
Longlong LUO
1
;
Xiaofeng ZHENG
2
;
Chun GAO
1
;
Xiaohui YU
1
;
Jiucong ZHANG
1
Author Information
- Publication Type:Review
- Keywords: Autophagy; Acetaminophen; Chemical and Drug Indued Liver Injury; Pathologic Processes
- From: Journal of Clinical Hepatology 2025;41(2):389-394
- CountryChina
- Language:Chinese
- Abstract: N-acetyl-p-aminophenol （APAP） is an antipyretic analgesic commonly used in clinical practice， and APAP overdose can cause severe liver injury and even death. In recent years， the incidence rate of APAP-induced liver injury （AILI） tends to increase， and it has become the second most common cause of liver transplantation worldwide. Autophagy is a highly conserved catabolic process that removes unwanted cytosolic proteins and organelles through lysosomal degradation to achieve the metabolic needs of cells themselves and the renewal of organelles. A large number of studies have shown that autophagy plays a key role in the pathophysiology of AILI， involving the mechanisms such as APAP protein conjugates， oxidative stress， JNK activation， mitochondrial dysfunction， inflammatory response and apoptosis. This article elaborates on the biological mechanism of autophagy in AILI， in order to provide a theoretical basis for the treatment of AILI and the development of autophagy regulators.
