Role of alkaloid compounds in regulating chronic liver diseases

Yihui ZHENG; Jiahui WANG; Tiejian ZHAO; Xuelin DUAN; Lei WANG; Yang ZHENG; Shiquan YANG

Return

Role of alkaloid compounds in regulating chronic liver diseases

VernacularTitle:生物碱类化合物调控慢性肝病的作用及其机制
Author: Yihui ZHENG ¹ ; Jiahui WANG ¹ ; Tiejian ZHAO ¹ ; Xuelin DUAN ² ; Lei WANG ¹ ; Yang ZHENG ¹ ; Shiquan YANG ¹
Author Information

1. Department of Medicine， Faculty of Chinese Medicine Science， Guangxi University of Chinese Medicine， Nanning 530222， China
2. School of Zhuang Medicine， Guangxi University of Chinese Medicine， Nanning 530222， China
Publication Type:Review
Keywords: Alkaloids; Liver Diseases; Signal Transduction
From: Journal of Clinical Hepatology 2025;41(2):375-382
CountryChina
Language:Chinese
Abstract: Chronic liver diseases with common causes including viral infections， alcohol abuse， and autoimmune diseases. Alkaloids， as a class of plant-derived compounds， have shown significant potential in regulating chronic liver diseases. Recent studies have shown that alkaloids are able to exert a therapeutic effect on chronic liver diseases through multiple pathways. These compounds have a regulatory effect on key pathological processes such as liver fibrosis， inflammatory response， oxidative stress， and cell apoptosis， and they also regulate the metabolic homeostasis of hepatocytes by modulating multiple signaling pathways， thereby playing a role in regulating chronic liver diseases. This article reviews the role and mechanism of alkaloids in the treatment of chronic liver diseases， in order to provide new ideas and directions for the treatment of chronic liver diseases.