New insights and prospects of drug-induced liver injury in the context of chronic cholestatic liver diseases

VernacularTitle:慢性胆汁淤积性肝病基础上发生药物性肝损伤的新见解与展望
Author: Simiao YU ¹ ; Jiabo WANG ² ; Xiaohe XIAO ¹ ; Ruilin WANG ¹
Author Information

1. Department of Traditional Chinese Medicine for Liver Diseases， The Fifth Medical Center of Chinese PLA General Hospital， Beijing 100039， China
2. School of Traditional Chinese Medicine， Capital Medical University， Beijing 100069， China
Publication Type:Review
Keywords: Cholestatic Liver Disease; Chemical and Drug Induced Liver Injury; Diagnosis， Differential
From: Journal of Clinical Hepatology 2025;41(2):365-369
CountryChina
Language:Chinese
Abstract: Patients with chronic cholestatic liver diseases face numerous challenges in the detection， assessment， and management of suspected drug-induced liver injury （DILI）， and in particular， it is difficult to distinguish cholestatic DILI from the progression of underlying cholestatic liver diseases clinically and histologically. Currently， there is a lack of related research and management guidelines for DILI with chronic cholestatic liver diseases. This article discusses the potential risks， causality， and classification criteria for chronic cholestatic liver diseases with DILI， in order to improve the understanding of such diseases among clinicians and provide a reference for prevention， treatment， and management strategies.