Molecular mechanisms of the interaction between hepatitis B virus infection and mitochondrial homeostasis
- VernacularTitle:HBV感染与线粒体稳态相互作用的分子机制
- Author:
Xingtong LI
1
;
Taicheng ZHOU
1
Author Information
- Publication Type:Review
- Keywords: Hepatitis B Virus; Mitochondria; Mitochondrial Dynamics; Mitophagy; Oxidative Phosphorylation
- From: Journal of Clinical Hepatology 2025;41(2):343-348
- CountryChina
- Language:Chinese
- Abstract: Hepatitis B virus （HBV） infection can cause acute or chronic infection， while untreated patients can develop into liver cirrhosis or liver cancer， thereby leading to death. As one of the most important organelles of cells， the maintenance of the normal morphology and function of mitochondria is the basis for ensuring various physiological activities in cells， and physiological activities， such as mitochondrial dynamics， mitophagy， injury， and oxidative phosphorylation， can affect the maintenance of mitochondrial homeostasis. HBV infection can affect mitochondrial homeostasis. This article summarizes the research advances in mitochondrial homeostasis and HBV infection from the four aspects of mitochondrial dynamics， mitophagy， mitochondrial oxidative phosphorylation， and mitochondrial injury and discusses the association between the maintenance of mitochondrial homeostasis and HBV infection， in order to provide a theoretical basis for understanding the molecular mechanism of HBV infection and identifying the potential therapeutic targets for HBV.
