Association of menopausal time and menopausal age with nonalcoholic fatty liver disease： An analysis based on a restricted cubic spline model
- VernacularTitle:基于限制性立方样条模型分析绝经时间、绝经年龄与非酒精性脂肪性肝病的关系
- Author:
Chenlu ZHAO
1
;
Suping MA
1
;
Dongfang SHANG
1
;
Sutong LIU
1
;
Xiaoyan LIU
1
;
Yuanyuan ZHENG
2
;
Wenxia ZHAO
1
Author Information
- Publication Type:Journal Article
- Keywords: Non-alcoholic Fatty Liver Disease; Menopause; Restricted Cubic Spline
- From: Journal of Clinical Hepatology 2025;41(2):247-253
- CountryChina
- Language:Chinese
- Abstract: ObjectiveTo investigate the association of menopausal time and menopausal age with the risk of nonalcoholic fatty liver disease （NAFLD）， and to provide a basis for the early prevention and treatment of NAFLD in clinical practice. MethodsRelated data were collected from 373 postmenopausal women who attended the outpatient service of Department of Spleen， Stomach， Liver and Gallbladder Diseases， The First Affiliated Hospital of Henan University of Chinese Medicine， from January 2017 to December 2021， including general information， menopausal age， menopausal time， and presence or absence of NAFLD. The chi-square test was used for comparison of categorical data； the independent-samples t test was used for comparison of normally distributed continuous data between groups， and the Wilcoxon rank-sum test was used for comparison of non-normally distributed continuous data between groups. A Logistic regression analysis was used to calculate the association intensity and 95% confidence interval （95%CI） of menopausal time and menopausal age for the risk of NAFLD， and the restricted cubic spline （RCS） method was used to investigate the dose-response relationship between menopausal time/age and the risk of NAFLD. ResultsCompared with the women with normal menopause or late menopause， the women with early menopause had a higher prevalence rate of NAFLD and a higher degree of steatosis and fibrosis （all P<0.05）. After adjustment for the confounding factors such as age and age of menarche， the risk of NAFLD in women with a menopausal time of >3 years was 4.80 （95%CI： 1.93 — 11.95， P=0.001） times that in women with a menopausal time of ≤3 years， and the risk of NAFLD in women with early or late menopause was 8.14 times （95%CI： 1.77 — 37.58， P=0.007） and 0.09 times （95%CI： 0.03 — 0.32， P<0.001）， respectively， that in those with a normal menopausal age. There is a dose-response relationship between menopausal time/age and the risk of NAFLD. Menopausal time is positively correlated with the association intensity of NAFLD， while menopausal age is negatively correlated with the association intensity of NAFLD. ConclusionThe longer the menopause time and the earlier the menopause age， the ligher the risk of NAFLD.
