Effect of Low Level Laser Therapy on Healing of Open Skin Wounds in Rats.
- Author:
Sang Woo YOU
1
;
Kyung Wook KIM
;
Jae Hoon LEE
;
Chang Jin KIM
Author Information
1. Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University.
- Publication Type:Original Article
- Keywords:
LLLT(Low level laser therapy);
Epithelial growth
- MeSH:
Animals;
Blood Vessels;
Collagen;
Edema;
Fibroblasts;
Hair;
Hair Follicle;
Keratinocytes;
Low-Level Light Therapy*;
Rats*;
Skin*;
Wound Healing;
Wounds and Injuries*
- From:Journal of the Korean Association of Oral and Maxillofacial Surgeons
2000;26(5):481-489
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
This research was focused on overall examination of tissue alteration, wound healing promotion. After the hair on the dorsal surface was shaved, 5x5mm oval skin defect was formed. Experimental wounds of right side were irradiated on every day for 90 second with Ga-Al-As semi-conductor laser. Left side wounds served as control group. The rats were sacrificed on the 1st, 3rd, 5th, 7th, 14th, 21th day. For light microscopically, parafin section were stained with H&E, MT. The outcomes were as follows : 1. On 1st day, experimental and control group were seen acute inflammatory cell infiltration, edema. 2. On the 3rd days, both groups were seen crust development, collagen, blood vessel proliferation. 3. On the 5th days, experimental group were reduced edema and inflammatory cell infiltration than control group. 4. On the 7th days, both groups were observed edema, inflammatory cell infiltration disappearance and keratinocytes motility from wound defect. 5. On the 14th days, experimental group appeared collagen, blood vessel proliferation and hair follicle than control group. 6. On the 21th days, both groups were seen normal status re-epithelization. According to the above results, The wound-healing stimulated by laser radiation involves an increased rate of epithelial growth. LLLT was confirmed that it has fibroblast, blood vessel proliferation, influence initial wound healing process.
