Research Progress of IL-13 Regulating Mucus Hypersecretion in Allergic Rhinitis and the Intervention of Traditional Chinese Medicine
- VernacularTitle:IL-13调控变应性鼻炎黏液高分泌及中药干预作用的研究进展
- Author:
ZHAO Yue
1
;
WANG Zhiwang
1
;
HUANG Keting
1
;
LIANG Keke
1
;
QUAN Ping
1
;
ZHANG Yue
1
Author Information
- Publication Type:Journal Article
- Keywords: allergic rhinitis; mucus hypersecretion; interleukin-13; signaling pathway; traditional Chinese medicine
- From: Chinese Journal of Modern Applied Pharmacy 2024;41(13):1836-1843
- CountryChina
- Language:Chinese
- Abstract: Allergic rhinitis(AR) is an allergic inflammatory disease of the nasal mucosa in which the immune inflammatory response alters the local microenvironment of the nasal mucosa, causing mucus hypersecretion as one of the main pathological features of AR. Interleukin-13(IL-13) is the main inflammatory factor secreted by Th2 cells, it can be involved in AR mucus hypersecretion process by regulating Goblet cell proliferation and Mucin 5ac expression through various signaling pathways. Traditional Chinese medicine has obvious advantages in the treatment of AR and its mucus hypersecretion, while the IL-13-mediated signaling pathways are one of the important mechanisms in treating AR mucus hypersecretion. This article reviews the regulation of IL-13-mediated signaling pathways on AR mucus hypersecretion and the intervention effects of traditional Chinese medicine, which providing a theoretical basis for experimental research and new drug development in AR mucus hypersecretion.
