Research Progress of Pharmacokinetics Studies of Anti-tumor Drugs in Patients with Third Space Fluid
- VernacularTitle:抗肿瘤药物在伴第三间隙积液患者中的药动学研究进展
- Author:
XU Gaoqi
1
;
YANG Dihong
1
;
XIN Wenxiu
1
;
DING Haiying
1
;
ZHU Junfeng
1
;
ZHONG Like
1
;
HE Chaoneng
1
;
FANG Luo
1
Author Information
- Publication Type:Journal Article
- Keywords: anti-tumor drugs; third space fluid; pharmacokinetics
- From: Chinese Journal of Modern Applied Pharmacy 2023;40(12):1596-1602
- CountryChina
- Language:Chinese
- Abstract: Third space fluid(TSF) is a common complication of advanced malignancies, including malignant pleural effusion, malignant ascites, intracranial effusion, and pelvic effusion, etc. The pharmacokinetics(PK) of anti-tumor drugs in vivo are influenced by various factors, and TSF is one of the potential factors that contributes to PK variations, which may consequently affect the efficacy and safety of anti-tumor drugs. This paper aimed to comprehensively investigate PK studies related to anti-tumor drugs in patients with malignant tumors accompanied by TSF. The paper summarized the PK characteristics of common cytotoxic drugs, small molecule targeted drugs, and monoclonal antibodies in both blood and TSF.
