Survival differences between endoscopic treatment and surgical treatment for patients with T1-2N0M0 duodenal neuroendocrine tumor

Bin BAI; Xian SU; Haibei XIN; Minfeng ZHANG; Hua XIAO; Hui CAI

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Survival differences between endoscopic treatment and surgical treatment for patients with T_1-2N₀M₀ duodenal neuroendocrine tumor

VernacularTitle:T_1～2N₀M₀期十二指肠神经内分泌肿瘤患者内镜治疗与手术治疗的生存差异
Author: Bin BAI ^{1
,

2} ; Xian SU ³ ; Haibei XIN ³ ; Minfeng ZHANG ³ ; Hua XIAO ⁴ ; Hui CAI ⁵
Author Information

1. Department of Hepatobiliary Surgery, Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China
2. Department of General Surgery, Baoshan Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201900, China.
3. Department of Hepatobiliary Surgery, Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China.
4. Department of Respiratory, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China.
5. Department of General Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, China.
Publication Type:Shortarticle
Keywords: duodenal neuroendocrine tumor; endoscopic treatment; surgical treatment; SEER database; survival
From: Chinese Journal of Clinical Medicine 2025;32(1):108-113
CountryChina
Language:Chinese
Abstract: Objective To compare the long-term survival outcomes of patients with T_1-2N₀M₀ duodenal neuroendocrine tumor (DNET) after endoscopic resection (ER) or surgical resection (SR). Methods Patients diagnosed with T_1-2N₀M₀ DNET between January 1, 2004, and December 31, 2015, were extracted from the SEER database. Kaplan-Meier survival curve and log-rank test were used to compare overall survival (OS) rate and cancer-specific survival (CSS) rate between patients undergoing ER or SR. Propensity score matching (PSM) was used to reduce grouping differences, and multivariate Cox regression was used to analyze factors affecting OS and CSS before and after PSM. Results A total of 656 patients were included, with 457 in ER group and 199 in SR group. Before PSM, there was no significant difference in the 5-year OS rate between the ER and SR groups (88.9% vs 89.6%), but there was a significant difference in the 5-year CSS rate (99.3% vs 96.9%, P＝0.017). Before PSM, multivariate Cox regression analysis showed advanced age was an independent risk factor for decreased OS (P＜0.001). After PSM, there was no significant difference between the ER group (n＝187) and SR group (n＝187) in 5-year OS rate (90.2% vs 88.9%) or CSS rate (98.9% vs 96.7%). After PSM, multivariate Cox regression also showed advanced age was an independent risk factor for decreased OS, while resection method was not an independent factor for OS or CSS. Conclusions There is no significant difference in OS or CSS after endoscopic treatment and surgical treatments for patients with T_1-2N₀M₀ DNET, and advanced age is an independent factor for OS.