Research Progress of chitosan derivatives as materials for siRNA nano-delivery systems
10.13748/j.cnki.issn1007-7693.20222602
- VernacularTitle:壳聚糖衍生物作为siRNA纳米递送系统材料的研究进展
- Author:
XIONG Feng
1
;
SU Feng
2
,
3
;
CAO Junru
4
;
CHU Xiaoqin
1
;
HE Guangwei
1
,
2
Author Information
1. Anhui University of Chinese Medicine, Hefei 230012, China
2. Hefei Industrial Pharmaceutical Institute Co., Ltd., Hefei 230088, China
3. China Pharmaceutical University, Nanjing 211198, China
4. Anhui Medical University, Hefei 230032, China
- Publication Type:Journal Article
- Keywords:
siRNA;
delivery system;
gene silencing;
chitosan derivatives
- From:
Chinese Journal of Modern Applied Pharmacy
2023;40(13):1889-1896
- CountryChina
- Language:Chinese
-
Abstract:
Small interfering RNA(siRNA) has been the focus of attention in the field of drug development for its excellent properties such as efficiency, specificity and transient nature in treating diseases. However, the poor stability and low cellular uptake of naked siRNAs make it difficult for them to exert their gene silencing effects, a high-quality drug delivery system is needed to deliver them to target cells where they can function. Many nano delivery systems are no longer suitable for siRNA transport due to toxicity and drug loading problems, chitosan derivatives are beginning to receive widespread attention because of their high water solubility, safety and stability. This paper reviewed the research progress of chitosan derivatives as siRNA nano-delivery systems and provided a reference for researchers who are interested in the development of nano-delivery systems.
