Pathways Related to Osteoporosis Treatment with Active Ingredients of Scutellaria Baicalensis： A Review
10.13422/j.cnki.syfjx.20242003
- VernacularTitle:黄芩有效成分治疗骨质疏松症相关信号通路的研究进展
- Author:
Jianqiang DU
1
;
Wenxiu QIN
1
;
Xuesong YIN
2
;
Dan ZHAO
2
;
Zhicheng PAN
1
;
Qi ZHANG
3
;
Enpeng GU
4
Author Information
1. Tianjin University of Traditional Chinese Medicine（TCM），Tianjin 301617，China
2. Gansu University of Chinese Medicine，Lanzhou 730000，China
3. Binhai New Area Hospital of TCM（Fourth Teaching Hospital of Tianjin University of TCM）， Tianjin 300450，China
4. The Second Affiliated Hospital of Tianjin University of TCM，Tianjin 300250，China
- Publication Type:Journal Article
- Keywords:
osteoporosis;
Scutellaria baicalensis;
active ingredient;
bone metabolism;
signaling pathway
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(7):325-330
- CountryChina
- Language:Chinese
-
Abstract:
With the aging of the global population， osteoporosis （OP） is becoming a major public health concern worldwide. Currently， the commonly used anti-osteoporosis drugs in clinical practice have limited application due to many side effects. Therefore， developing more effective and safer strategies for the prevention and treatment of OP has become a research focus in this field. In recent years， the clinical efficacy and advantages of traditional Chinese medicine （TCM） in treating OP have been gradually recognized. With the deepening pharmacological research on TCM for OP prevention and treatment， it is found that the active ingredients of Scutellaria baicalensis can promote bone formation or inhibit bone resorption by regulating signaling pathways， including Wnt/β-catenin， osteoprotegerin （OB）/receptor activator of nuclear factor-κB ligand （RANKL）/RANK （OPG/RANKL/RANK）， and bone morphogenetic protein 2 （BMP-2）/Smad， mitogen-activated protein kinase （MAPK）， and mammalian target of rapamycin （mTOR）. However， existing research on active ingredients of S. baicalensis for OP treatment is scattered， making it difficult for scholars to gain a systematic understanding of its research and application. This review summarized the literature on the active ingredients of S. baicalensis in OP treatment worldwide， clarified their mechanisms of action， and explored some issues， providing references for the integration of TCM in OP prevention and treatment.
