Research Advances on Anti-inflammatory and Anti-oxidation Effect of Medicinal and Edible Herbs Liver-protecting Chinese Medicine
10.13422/j.cnki.syfjx.20241312
- VernacularTitle:药食同源保肝中药的抗炎抗氧化作用
- Author:
Jinghan ZHAO
1
;
Zhengwang ZHU
1
;
Linlin WANG
1
;
Pingsheng ZHU
1
;
Mingsan MIAO
2
Author Information
1. The First Clinical Medical College of Henan University of Chinese Medicine， Zhengzhou 450000，China
2. School of Pharmacy，Henan University of Chinese Medicine，Zhengzhou 450046，China
- Publication Type:Journal Article
- Keywords:
medicinal and edible herbs;
liver injury;
inflammatory response;
oxidative stress;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(7):293-301
- CountryChina
- Language:Chinese
-
Abstract:
The liver is closely associated with inflammation and the redox response， and inflammation is the body's innate defense system for clearing away harmful stimuli and participating in the liver's wound-healing response.Oxidative stress is associated with the activation of inflammatory pathways， and sustained inflammation and the corresponding regenerative wound healing response can induce fibrosis， cirrhosis， progression to end-stage liver disease or hepatocellular carcinoma， and ultimately death.Some "medicine and food homology" traditional Chinese medicine has been used in clinical effect， showing the ability to protect the liver.This paper reviewed the relationship between liver and oxidative stress response and inflammation response， and sorted out 110 "medicine and food same origin" traditional Chinese medicines based on the Chinese Pharmacopoeia（2020 edition） and the Chinese materia medica.The results showed that common floweringqince fruit， licorice root， cassia seed， emblic，seabuckthorn fruit，Chinese date， honeysuckle， ginger， cape jasmine fruit， platycodon root， lotus leaf， dandelion， reed root， honey， mountain honeysuckle， milkvetch root， glossy ganoderma， Gastrodia gastrodia and eucommia leaf were recorded to have liver protection effects.The liver protection mechanism is mainly anti-inflammatory， antioxidant and lipid peroxidation inhibition. Some Chinese herbs can also play a liver protection role by inhibiting the growth of hepatitis virus and liver cancer cells and regulating bile acid metabolism.In addition， the biological mechanism of its liver protection effect through antioxidant and anti-inflammatory effects in animal experiments was analyzed， and it was found that it plays a role through multiple pathways and multiple targets， providing new ideas for the role of "medicine and food homology" traditional Chinese medicine in the treatment strategy of liver diseases.
