Role of Autophagy in Cardiovascular Diseases and Traditional Chinese Medicine Treatment： A Review
10.13422/j.cnki.syfjx.20241537
- VernacularTitle:自噬在心血管疾病中的作用及中医药治疗进展
- Author:
Yiting ZHAO
1
;
Hewei QIN
1
;
Xia WEI
2
Author Information
1. Rehabilitation Medicine College， Henan University of Chinese Medicine ，Zhengzhou 450046， China
2. Zhumadian Hospital of Traditional Chinese Medicine， Zhumadian 463000， China
- Publication Type:Journal Article
- Keywords:
autophagy;
cardiovascular diseases;
traditional Chinese medical treatment;
mechanism of action;
review
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(7):284-292
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular diseases， a group of major non-infectious diseases， are characterized by high morbidity and mortality， significantly influencing patients' quality of life. Hence， it is imperative to discover a secure and efficacious treatment approach. As a form of programmed cell death， autophagy has been demonstrated to be associated with the pathogeneses of hypertension， diabetic cardiomyopathy， myocardial ischemia-reperfusion injury， heart failure， atherosclerosis， and other cardiovascular disorders. It serves as one of the potential targets for the clinical intervention in cardiovascular diseases by traditional Chinese medicine （TCM）. Autophagy exerts dual regulatory effects on the occurrence and development of cardiovascular diseases， and its specific effect predominantly depends on the extent of autophagy and the pathological stage of diseases. Recent studies have confirmed that TCM can prevent and treat cardiovascular diseases by directly regulating autophagy or interacting with oxidative stress， inflammation， and apoptosis under the regulation of autophagy， exhibiting the unique advantages of multiple targets， multiple components， and mild adverse reactions. This article reviews the experimental research progress in the role of autophagy and the intervention by active components and compound prescriptions of TCM and Chinese patent medicines in common cardiovascular diseases （such as diabetic cardiomyopathy， myocardial ischemia-reperfusion injury， heart failure， and atherosclerosis） in recent years and summarizes the research shortcomings， providing a theoretical basis and strategies for the clinical treatment of cardiovascular diseases.
