Pharmacological Mechanism of Huanglian Jiedutang： A Review
10.13422/j.cnki.syfjx.20250101
- VernacularTitle:黄连解毒汤的药理机制研究进展
- Author:
Duojing LI
1
;
Yongfa XING
2
;
Baohe WANG
3
Author Information
1. School of Graduate Studies，Tianjin University of Traditional Chinese Medicine（TCM）， Tianjin 301617，China
2. The Second Affiliated Hospital of Tianjin University of TCM，Tianjin 300250，China
3. First Teaching Hospital of Tianjin University of TCM，Tianjin 300193，China
- Publication Type:Journal Article
- Keywords:
Huanglian Jiedutang;
material basis;
pharmacokinetics;
pharmacological mechanism of action;
review
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(7):275-283
- CountryChina
- Language:Chinese
-
Abstract:
Huanglian Jiedutang （HLJDT）， a traditional Chinese herbal formula， is known for its heat-clearing and detoxifying effects. This article reviewed the material basis， pharmacological mechanism of action， and research on HLJDT. Modern research has shown that HLJDT is rich in alkaloids， flavonoids， glycosides， and other active ingredients. In terms of pharmacological mechanisms of action， HLJDT has anti-inflammatory and antibacterial effects， and it can regulate intestinal flora and cell disorder， improve iron metabolism disorder， control glucose and lipid metabolism， and exert vascular endothelial functions， with anti-tumor effects， thus improving cerebral ischemia and reducing liver damage. Its therapeutic actions are multi-layered， multi-faceted， and multi-targeted， showing significant efficacy in treating various diseases. Interdisciplinary research， such as the combined application of network pharmacology with molecular docking technology， as well as metabolomics with proteomics， has revealed the potential mechanism of HLJDT in treating various diseases. However， the research on HLJDT still faces some challenges， including the need for an in-depth exploration of its complex pharmacological mechanism of action， evaluation of its efficacy and safety across different diseases and populations， and quality control of traditional Chinese medicine. Future research should integrate modern scientific and technological approaches with traditional Chinese medicine principles to further investigate HLJDT's complex pharmacological mechanism of action， providing theoretical and practical support for its clinical use.
