Treatment of IgA Nephropathy by Tonifying Kidney and Invigorating Spleen as Well as Detoxifying and Relieving Sore-throat Based on PIgR-CR1-mediated Mucosal-renal Axis
10.13422/j.cnki.syfjx.20250191
- VernacularTitle:基于PIgR-CR1介导的“黏膜-肾轴”探析补肾健脾、解毒利咽法防治IgA肾病的研究思路
- Author:
Fan LI
1
;
Hongan WANG
2
;
He NAN
2
;
Mingyu HE
1
;
Chengji CUI
2
;
Yinping WANG
2
;
Yutong LIU
1
;
Shoulin ZHANG
2
Author Information
1. Changchun University of Chinese Medicine，Changchun 130117，China
2. Affiliated Hospital of Changchun University of Chinese Medicine，Changchun 130021，China
- Publication Type:Journal Article
- Keywords:
IgA nephropathy;
mucosal-renal axis;
polymeric Ig receptor;
complement receptor type 1 （CR1）;
tonifying kidney and invigorating spleen;
detoxifying and relieving sore-throat
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(7):237-244
- CountryChina
- Language:Chinese
-
Abstract:
Immunoglobulin A nephropathy （IgAN） is the primary glomerulonephritis with the highest incidence rate in the world. It is also the main cause of end-stage renal disease （ESRD） in China， which has brought heavy economic burden to the society and patient families. Traditional Chinese medicine （TCM） has certain advantages in treating IgAN. In TCM， IgAN is classified into consumptive disease， hematuria， and edema categories， with the location in the kidney and involving the lung， liver， and spleen. Professor Ren Jixue， a master of TCM， believes that kidney deficiency and spleen deficiency are the root causes of IgAN， and the throat is the source of the disease. He proposed the theory of throat-kidney correlation and used the method of tonifying kidney and invigorating spleen as well as detoxifying and relieving sore-throat to treat IgAN， achieving significant therapeutic effects. Studies have shown that IgAN is closely related to mucosal immune defense. IgAN patients often experience recurrent and gradually worsening symptoms due to mucosal infections， and polymeric Ig receptor （PIgR） is an important component of mucosal defense function. The lack of PIgR leads to the accumulation of IgA molecules in the mucosal lamina propria， and the molecules enter the bloodstream in large quantities and ultimately deposit in the kidneys， causing kidney damage. Complement regulatory protein complement receptor type 1 （CR1） exists on red blood cells and glomeruli and has the function of inhibiting the activation and differentiation of B cells， clearing immune complexes， and inhibiting excessive activation of the complement system. Therefore， regulating the immune defense function through the mucosal-renal axis mediated by PIgR-CR1 will be an important target for preventing and treating IgAN. Based on the theory of throat-kidney correlation， this article explores the effects and molecular mechanisms of tonifying kidney and invigorating spleen as well as detoxifying and relieving sore-throat in preventing and treating IgAN by regulating the mucosal-kidney axis mediated by PIgR-CR1. It provides effective theoretical support and a scientific basis for TCM prevention and treatment of IgAN based on the theory of throat-kidney correlation.
