Exploration of Traditional Chinese and Western Medicine in Prevention and Treatment of DKD Based on Mitochondrial Autophagy Mediated by PINK1/Parkin Signaling Pathway： A Review
10.13422/j.cnki.syfjx.20250697
- VernacularTitle:基于PINK1/Parkin信号通路介导的线粒体自噬探讨中西医防治糖尿病肾病的研究进展
- Author:
Runsheng LIU
1
;
Xiaodong ZHANG
2
;
Zhaoqing LI
1
;
Jing WANG
1
;
Jinglu ZHANG
1
;
Lixia JIN
2
Author Information
1. Heilongjiang University of Chinese Medicine，Harbin 150006，China
2. The Fourth Affiliated Hospital of Heilongjiang University of Chinese Medicine，Harbin 150070，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese and Western medicine;
diabetic kidney disease（DKD）;
PTEN-induced putative kinase 1 （PINK1）/Parkin signaling pathway;
mechanism of action;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(7):302-313
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic kidney disease （DKD） is one of the more common chronic kidney diseases，and its causes are complex. DKD is very easy to progress to end-stage renal disease，and the current therapeutic effect still needs to be improved. As an important excretive organ of the human body， the kidney has physiological functions such as discharging metabolic waste， regulating fluid balance， and maintaining the stability of the body's internal environment. These highly complex biochemical processes all depend on the energy support provided by mitochondria. Mitochondrial dysfunction is a key factor causing kidney injury， and the imbalance of mitochondrial homeostasis is an important link leading to mitochondrial dysfunction. The occurrence and development of DKD are often accompanied by the imbalance of mitochondrial homeostasis in renal cells. Mitochondrial autophagy， as a means of regulating mitochondrial homeostasis， is very important for the prevention and treatment of DKD. The PTEN-induced putative kinase 1 （PINK1）/Parkin pathway is one of the most classical pathways to regulate mitochondrial autophagy. Recent studies have found that some drugs can regulate the PINK1/Parkin signaling pathway to target mitochondrial homeostasis and exert renoprotective effects. In particular， traditional Chinese medicine has a significant effect on early and middle stage DKD by regulating PINK1/Parkin pathway-mediated mitochondrial autophagy. This article discussed the mechanism of PINK1/Parkin pathway in mitochondrial autophagy and DKD and reviewed the effect of PINK1/Parkin pathway-mediated mitochondrial autophagy on DKD. At the same time， it explored the therapeutic effect of traditional Chinese and western medicine on DKD mediated by PINK1/Parkin-mediated mitochondrial autophagy， aiming to broaden the ideas of traditional Chinese and western medicine for the prevention and treatment of DKD from the perspective of PINK1/Parkin regulating mitochondrial autophagy.
