Mechanism of Chinese Medicine in Promoting Angiogenesis After Ischemic Stroke Based on PI3K/Akt Signaling Pathway： A Review
10.13422/j.cnki.syfjx.20242029
- VernacularTitle:基于PI3K/Akt信号通路探讨中药促进缺血性脑卒中后血管新生的作用机制研究进展
- Author:
Xiaoya WANG
1
;
Haofei LIU
1
;
Xiangzhe LIU
1
Author Information
1. The First Affiliated Hospital of Henan University of Chinese Medicine， Zhengzhou 450000，China
- Publication Type:Review
- Keywords:
hosphatidylinositol 3-kinase （PI3K）/signaling protein kinase B （Akt） signaling pathway;
ischemic stroke;
Chinese medicine;
angiogenesis;
mechanism of action;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(7):265-274
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke is a common cerebrovascular disease， characterized by hypoxia and nutritional deficiency in local brain tissue due to insufficient blood supply. Angiogenesis， the formation of new vascular networks on the basis of existing blood vessels， is of great significance for increasing blood flow in the ischemic area of brain tissue， restoring blood and oxygen supply， and improving disease prognosis. This complex process is regulated by various factors， including cytokines， growth factors， and signaling pathways. Among these， the phosphatidylinositol 3-kinase （PI3K）/protein kinase B （Akt） signaling pathway is considered a key regulatory pathway. It not only plays an important role in anti-apoptosis and promoting cell survival， but also regulates cell growth， differentiation， migration， and survival， while deeply participating in the regulation of angiogenesis. Chinese medicine offers unique advantages with its multi-component， multi-target， and multi-pathway approach in the treatment of stroke， showing significant potential in treating ischemic stroke. In recent years， it has been found that Chinese medicine can promote angiogenesis after ischemic stroke through the PI3K/Akt signaling pathway. This paper focuses on the PI3K/Akt signaling pathway as the research entry point， and explores in-depth the mechanisms by which Chinese medicine monomers， active components， extracts， derivatives， drug pairs， and Chinese medicine compounds promote angiogenesis after ischemic stroke. The research discusses the regulation of microRNAs （miRNA）， endothelial progenitor cells （EPCs）， apoptosis， upstream pro-angiogenic factors， and downstream target molecules. The paper also elaborates on related research progress， aiming to reveal how Chinese medicine can exert its potential utility in ischemic stroke treatment through this key signaling pathway， providing a theoretical basis for clinical treatment.
