Associations between TBX21 Gene Polymorphisms and Korean Patients with Behcet's Disease.
10.4078/jkra.2010.17.4.360
- Author:
Jae Hee HWANG
1
;
Ju Kyoung SONG
;
In Seol YOO
;
Seung Taek SONG
;
Jin Hyun KIM
;
Yun Jong LEE
;
Young Deok BAE
;
Hyo Jin CHOI
;
Han Joo BAEK
;
Seong Wook KANG
Author Information
1. Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea. kangsw@cnuh.co.kr
- Publication Type:Original Article
- Keywords:
TBX21 gene polymorphisms;
Behcet's disease
- MeSH:
Arthritis;
Central Nervous System;
Exons;
Genotype;
Humans;
Polymorphism, Restriction Fragment Length;
Polymorphism, Single Nucleotide;
Promoter Regions, Genetic;
Th1 Cells;
Transcription Factors
- From:The Journal of the Korean Rheumatism Association
2010;17(4):360-367
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: Behcet's disease (BD) is a chronic systemic inflammatory disease with unknown etiology. A number of clinical and laboratory findings suggest a strongly polarized Th1 immune response in BD. T-bet is a newly identified Th1 specific T-box transcription factor selectively expressed in Th1 cells. However, it is not yet clear whether the T-bet protein is involved in the proposed Th1-mediated pathogenesis of BD at the transcriptional level. Therefore, this study investigated the potential associations of two single nucleotide polymorphisms (SNPs) at positions -99 (C/G) and -1993 (T/C) in the exon and promoter regions of the TBX21 gene with susceptibility to BD in the Korean population. METHODS: 105 patients with BD and 105 healthy controls were studied. All subjects were genotyped using restriction fragment length polymorphism analysis. The genotypes of the two groups were compared with the chi-square or Fisher's exact tests. RESULTS: The genotypic and allelic distributions of the two SNPs did not differ significantly between the two groups. Furthermore, no associations between the polymorphisms and clinical manifestations were found, except a central nervous system manifestation and arthritis. Furthermore, no associations between the polymorphisms and severity were identified. CONCLUSION: TBX21 gene polymorphisms were not associated with susceptibility, clinical manifestations, or severity of BD in the Korean population.
