Research Progress and Application of Celastrol in Glioma
10.13748/j.cnki.issn1007-7693.20223202
- VernacularTitle:雷公藤红素在胶质细胞瘤中的研究进展及应用
- Author:
TANG Ke
1
,
2
;
TAN Qinyou
1
,
2
,
3
Author Information
1. Department of Clinical Pharmacy and Clinical Pharmacology, Affiliated Hospital of Guilin Medical College, Guilin 541001, China
2. School of Pharmacy, Guilin Medical College, Guilin 541199, China
3. China-US Lipid Research Center for Health and Disease, Guilin 541001, China
- Publication Type:Journal Article
- Keywords:
celastrol;
glioma;
nanocarriers;
hepatotoxicity;
blood-brain barrier
- From:
Chinese Journal of Modern Applied Pharmacy
2023;40(13):1881-1888
- CountryChina
- Language:Chinese
-
Abstract:
Celastrol(Cel) is a active ingredient extracted from the natural compound Tripterygium wilfordii, which has good anti-tumor activity and other pharmacological effects. In recent years, studies have found that Cel has good anti-tumor activity and the ability to penetrate the blood-brain barrier(BBB), which is a potential drug for treating brain tumors. However, due to its severe liver toxicity, its clinical application prospects are questioned. Glioma(GMA) is a high incidence tumor in the brain, with a survival rate of<5% after diagnosis. Currently, there are few drugs available in clinical practice, so it is urgent to explore new drugs or drug delivery strategies to treat neuro GMA. Some studies have found that Cel has good anti-tumor activity and also has a good inhibitory effect on GMA, but the relevant mechanisms have not yet been systematically summarized and expanded. Since Cel still faces many problems in its clinical application in GBA, it is necessary to further consider what means to use in the future to enable Cel to efficiently pass through BBB and deliver it to the GMA site for Targeted therapy while reducing its hepatotoxicity. This article summarizes and expands the mechanisms and research results of Cel in various tumors and GMA in recent years. This article also reviews the new applications of Cel combined with nanocarriers in enhancing efficacy and reducing toxicity in recent years, in order to more clearly summarize the role of Cel in the treatment of GMA and how to systematically summarize the delivery methods of Cel through BBB, providing new treatment methods for clinical treatment of GMA.
