Prediction of Platycodonis Radix Quality Marker Based on Network Pharmacology and Chemometrics Methods
10.13748/j.cnki.issn1007-7693.20222301
- VernacularTitle:基于网络药理学和化学计量学方法预测桔梗的质量标志物
- Author:
YANG Yiliu
1
;
YU Qian
1
;
XIAO Fengqin
1
;
LIU Hui
1
;
LI Jia
1
;
YAN Mingming
1
,
2
,
3
;
LI Guangzhe
1
Author Information
1. Changchun University of Chinese Medicine, Changchun 130117, China
2. Jilin Provincial Science &
3. Technology Innovation Center of Health Food of Chinese Medicine, Changchun 130117, China
- Publication Type:Journal Article
- Keywords:
Platycodonis Radix;
network pharmacology;
fingerprint;
content determination;
quality markers
- From:
Chinese Journal of Modern Applied Pharmacy
2023;40(13):1785-1794
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To preliminary predict and analyze the quality marker(Q-markers)of Platycodonis Radix decoction based on the validity and measurability of traditional Chinese medicine Q-marker. METHODS The fingerprints of 20 batches of Platycodonis Radix samples were established, and the similarity was evaluated. At the same time, a "component-target-pathway" network diagram was constructed through network pharmacology to predict the potential active components of Platycodonis Radix. Mathematical analysis methods such as principal component analysis and orthogonal partial least-squares discrimination analysis were used to screen differential components; the content of candidate components were determined. RESULTS There were 19 common peaks in the established fingerprint, and 8 common components were identified as candidate active components for network pharmacology analysis. Network pharmacology indicated that 6 compounds were screened out with a high degree of connectivity. Based on the comprehensive consideration of Q-marker principle:traceability and transmissibility, specificity, efficacy, and measurability, luteolin, syringin, chlorogen acid, platycoside D, platycoside D3 and platycoside E were preliminarily predicted as potential Q-markers of platycodon. CONCLUSION The prediction analysis of Platycodonis Radix Q-marker provides a reference for the comprehensive control of the quality of Platycodonis Radix medicinal materials, and also lays a foundation for the research and exploration of the substance basis and mechanism of action of Platycodonis Radix.
