Causal Relationships Between Immune Cells and Risk of Gastric Cancer: A Mendelian Randomization Study
10.3971/j.issn.1000-8578.2025.24.0438
- VernacularTitle:基于孟德尔随机化研究免疫细胞与胃癌发病风险的因果关系
- Author:
Jiawei HE
1
;
Longnyu CAO
2
;
Mengyuan TANG
1
;
Hongquan CUI
2
Author Information
1. College of Traditional Chinese Medicine Clinical Medicine, Hubei University of Chinese Medicine, Wuhan 431061, China.
2. Department of Oncology, Suzhou Jiulong Hospital, School of Medicine, Shanghai Jiao Tong University, Suzhou 215018, China.
- Publication Type:CLINICALRESEARCH
- Keywords:
Immune cells;
Gastric cancer;
Mendelian randomization;
Causal effects
- From:
Cancer Research on Prevention and Treatment
2025;52(2):172-176
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the causal relationship between immune cell phenotype and gastric cancer. Methods Bidirectional two-sample Mendelian randomization (MR) analysis was used to select 731 genetic variants involving immune cell phenotypes from the GWAS dataset as instrumental variables. Inverse-variance weighting method (IVW), weighted median method (WM), and MR-Egger regression were used for sensitivity analysis. Cochran Q test, MR-Egger regression, MR-PRESSO method, and remain-one method were also conducted. Results Changes in the absolute count of IgD+ B cells and CD14-CD16- cells were significantly associated with the risk of gastric cancer. A lower proportion of IgD+ B cells was associated with a lower risk of gastric cancer (OR=0.86, 95%CI: 0.79-0.94), while an increased number of CD4-CD8-T cells was associated with an increased risk of gastric cancer (OR=1.2, 95%CI: 1.1-1.3). Conclusion A causal relationship exists between immune cell phenotype and the risk of gastric cancer. Changes in specific immune markers may regulate the development of gastric cancer by affecting the tumor microenvironment.
