Exploring the Correlation between Pyroptosis and Immune Microenvironment Dysregulation in Rheumatoid Arthritis from the Perspective of "Ying Decline and Wei Attack"
10.13288/j.11-2166/r.2025.05.006
- VernacularTitle:从“营衰卫伐”探讨细胞焦亡与类风湿关节炎免疫微环境失调的相关性
- Author:
Yancun LI
1
;
Shu ZHU
1
;
Yuhan WANG
1
;
Yuan QU
1
;
Yuan LIU
1
;
Ping JIANG
1
Author Information
1. Shandong University of Traditional Chinese Medicine，Jinan，250355
- Publication Type:Journal Article
- Keywords:
rheumatoid arthritis;
pyroptosis;
immune microenvironment;
ying decline and wei attack
- From:
Journal of Traditional Chinese Medicine
2025;66(5):464-467
- CountryChina
- Language:Chinese
-
Abstract:
As a complex autoimmune disease， rheumatoid arthritis （RA） involves immune microenvironment dysregulation resulting from excessive activation of pyroptosis， which is a crucial factor in disease progression. Based on the theory of ying-wei in traditional Chinese medicine， "ying decline and wei attack" is considered the fundamental pathogenesis of RA. Pyroptosis serves as a microscopic manifestation of this concept， suggesting a potential correlation between "ying decline and wei attack" and pyroptosis nd immune microenvironment dysregulation in RA. Accordingly， treatment principles based on this theory are proposed： in the early stage of the disease， boosting wei to consolidate the exterior， and regulating ying to dispel pathogens； in the middle and late stages， harmonizing ying to remove stagnation， and nourishing its transformational source.
