Research progress on the anti-tumor effects of traditional Chinese medicine through intervention in the Nrf2/GPX4 signaling pathway
- VernacularTitle:中药干预Nrf2/GPX4信号通路抗肿瘤作用的研究进展
- Author:
Jie HUANG
1
;
Si LIN
1
,
2
;
Chunjuan JIANG
1
;
Ling WEI
1
Author Information
1. Dept. of Pharmacy，the Second Affiliated Hospital of Guangxi Medical University，Nanning 530007，China
2. Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine，Guangxi University of Chinese Medicine，Nanning 530200，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
Nrf2/GPX4 signaling pathway;
anti-tumor;
effective components;
extract
- From:
China Pharmacy
2025;36(4):507-512
- CountryChina
- Language:Chinese
-
Abstract:
Nuclear factor-erythroid 2-related factor 2 （Nrf2）/glutathione peroxidase 4 （GPX4） signaling pathway plays a key role in the occurrence and development of tumors， and is involved in tumor cell proliferation， apoptosis， ferroptosis， invasion， migration， and drug resistance. Based on the Nrf2/GPX4 signaling pathway， this paper summarizes the research progress of the anti- tumor effects of traditional Chinese medicine. It is found that flavonoids （ginkgetin， luteolin， etc.）， terpenoids （atractylenolide， cucurbitacin B， etc.）， saponins （polyphyllin Ⅰ， polyphyllin Ⅶ）， ester （brusatol） and other effective components， and traditional Chinese medicine extracts （total coumarins in Pileostegia tomentella and total flavonoids of Pterocarya hupehensis Skan）， traditional Chinese medicine compounds （Fushao diqin fang， Xiaoai jiedu fang， etc.） can promote ferroptosis in tumor cells by inhibiting Nrf2/GPX4 signaling pathway and the expressions of its upstream and downstream factor proteins， as well as by increasing Fe2+ levels and lipid peroxidation， thereby exerting an antitumor effect.
