Study on the Pharmacodynamic Substances and Quality Control of Shenfukang II Capsules Based on Fingerprint and Network Pharmacology
10.13748/j.cnki.issn1007-7693.20222478
- VernacularTitle:基于指纹图谱和网络药理学的肾复康Ⅱ号胶囊的药效物质和质量控制研究
- Author:
YIN Jiyao
1
;
HU Jing
2
,
3
;
SHEN Xia
1
;
CUI Xiaomin
2
,
3
;
REN Hui
2
,
3
;
QU Tong
2
,
3
;
LI Ning
2
,
3
;
LU Wenjin
2
,
3
;
CHEN Zhiyong
1
,
2
,
3
Author Information
1. Shaanxi University of Chinese Medicine, Xianyang 712083, China
2. Shaanxi Academy of Traditional Chinese Medicine, Xi'
3. an 710003, China
- Publication Type:Journal Article
- Keywords:
Shenfukang Ⅱ capsule;
fingerprints;
indicative compounds;
network pharmacology;
morroniside;
paeoniflorin
- From:
Chinese Journal of Modern Applied Pharmacy
2023;40(13):1765-1774
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To establish the fingerprint of Shenfukang Ⅱ capsule(SC-Ⅱ), and to screen out its indicative compounds for quality control combined with chemometrics methods and network pharmacology. METHODS The HPLC fingerprint of 10 batches of SC-Ⅱ was established, and similarity evaluation was analyzed by Similarity Evaluation System for Chromatographic Fingerprint of TCM(2012 A Edition) to determine common peaks; common peaks were identified through standard comparison. Chemometrics methods was used to evaluate quality of 10 batches of SC-Ⅱ, and network pharmacology was used to screen out core targets and pathways of SC-Ⅱ. Combined with the above results, indicative compounds for quality control of SC-Ⅱ were screened out. RESULTS A total of 37 common peaks were obtained in the HPLC fingerprint, the similarity of samples was greater than 0.97. Twenty compounds were identified as morroniside, loganin, paeoniflorin and et al. The samples were divided into two categories by chemical pattern recognition, salvianolic acid B, morroniside, salvianolic acid A and paeoniflorin were differential marker compounds for SC-Ⅱ. Network pharmacology predicted that active compounds such as salvianolic acid B, paeoniflorin and morroniside might exert pharmacological effects through 45 core targets and 15 main pathways. The research preliminary preliminarily predicted that morroniside, paeoniflorin and salvianolic acid B were quality control index components for SC-II. CONCLUSION The established HPLC fingerprint method is simple and good repeatability. The quality control indicative compounds of SC-Ⅱ can provide a basis for its quality control.
