Mechanism of Action of Ca2+/Calmodulin Dependent Protein Kinase II in Heart Failure and the Progress of Its Application in Traditional Chinese Medicine Treatment
10.13748/j.cnki.issn1007-7693.20222695
- VernacularTitle:Ca2+/CaM依赖性蛋白激酶II在心力衰竭中的作用机制及中医药治疗应用进展
- Author:
BAI Tingyan
1
;
YI Xishan
1
;
ZHAO Xinke
1
;
LIU Kai
1
;
JIANG Hugang
1
;
LI Yingdong
1
,
2
Author Information
1. Gansu University of Chinese Medicine, Lanzhou 730000, China
2. Affiliated Hospital of Gansu University of Chinese 1. Jining Medical University, Institute of Behavioral Medicine Education, 2. Jining Medical University, Institute of Precision Medicine, Jining 272067, China
- Publication Type:Journal Article
- Keywords:
heart failure;
CaMKII signaling pathway;
mechanism;
traditional Chinese medicine;
research progress
- From:
Chinese Journal of Modern Applied Pharmacy
2023;40(14):2023-2031
- CountryChina
- Language:Chinese
-
Abstract:
Heart failure is a common frequently-occurring disease, and it is the terminal stage of the development of various heart diseases. The pathogenesis is very complex and seriously endangers human health. A large number of studies have shown that Ca2+/Calmodulin dependent protein kinase II(CaMKII) plays an important role in the occurrence and development of heart failure. Traditional Chinese medicine has unique advantages and good prospects in the prevention and treatment of heart failure. Among them, there are many compound and their active ingredients can target and regulate CaMKII. This paper mainly expounds the mechanism of the CaMKII signaling pathway in the failing heart and the research progress of traditional Chinese medicine in preventing and treating heart failure by targeting the regulation of CaMKII signaling in recent years, in order to provide reference and expand ideas for clinical traditional Chinese medicine prevention and treatment in heart failure.
