Influence of Vitamin D Receptor Genetic Polymorphism in Recipients on Concentration of Tacrolimus in the Early Stage After Renal Transplantation
10.13748/j.cnki.issn1007-7693.20221989
- VernacularTitle:维生素D受体基因多态性对肾移植患者术后早期他克莫司浓度的影响
- Author:
HU Nan
1
,
2
;
ZOU Sulan
1
,
2
;
JIANG Yan
1
,
2
;
YANG Xuping
1
,
2
;
DONG Lulu
1
,
2
;
LING Jing
1
,
2
Author Information
1. Department of Pharmacy, The First People'
2. s Hospital of Changzhou/The Third Affiliated Hospital of Soochow University, Changzhou 213003, China
- Publication Type:Journal Article
- Keywords:
renal transplantation;
CYP3A5;
vitamin D receptor(VDR);
genetic polymorphism;
tacrolimus;
drug concentration;
dosage
- From:
Chinese Journal of Modern Applied Pharmacy
2023;40(14):1996-2000
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the effect of vitamin D receptor(VDR) genetic polymorphism on the concentration of tacrolimus in renal transplant recipients at early stage after transplantation.METHODS The 360 cases of renal transplant recipients who received tacrolimus, mycophenolic acid, and glucocorticoid were recruited. CYP3A5(rs776746) and VDR(VDR ApaI rs7975232, VDR BsmI rs1544410, VDR FokI rs2228570 and VDR TaqI rs731236) genotypes were determined. The differences of concentration(C), dose(D) and the ratio of concentration to dose(C/D) of tacrolimus were compared among all of the genotype groups at the seventh day after renal transplantation. RESULTS The C and C/D of tacrolimus in CYP3A5 non-expresser(GG genotype) were all significantly higher than CYP3A5 expresser(AA and AG genotype)(P<0.05). When taking the different CYP3A5 genotypes in consideration, it was found that the C/D in patients with VDR ApaI rs7975232 AA genotype was significantly lower than those with AC and CC genotypes for CYP3A5 non-expresser(P<0.05). However, VDR ApaI rs7975232 gene polymorphism had no influence on C and C/D of tacrolimus in CYP3A5 expresser. Besides, no matter in CYP3A5 expresser or in non-expresser, VDR BsmI rs1544410, VDR TaqI rs731236 and VDR FokI rs2228570 had no effect on C, D and C/D of tacrolimus. CONCLUSION During the early stage of renal transplantation, the polymorphism of VDR ApaI rs7975232 show significant relevance with tacrolimus concentration in CYP3A5 non-expresser. The detection of the genotype might be helpful to guide individual therapy.
