Study on the antibacterial properties of Copper-Gadolinium nanomaterials against Escherichia coli
10.19405/j.cnki.issn1000-1492.2024.12.013
- Author:
Qing Li
1
,
2
;
Yuanchun Si
1
,
2
;
Zhengyan Wu
1
,
3
,
4
;
Jia Zhang
5
;
Yuanyin Wang
1
,
2
Author Information
1. College &
2. Hospital of Stomatology , Anhui Medical University , Anhui Provincial Key Laboratory of Oral Disease Research , Hefei 230032
3. Hospital of Stomatology , Anhui Medical University , Anhui Provincial Key Laboratory of Oral Disease Research , Hefei 230032
4. Institute of Intelligent Machines , Hefei Institutes of Physical Science , Chinese Academy of Sciences , Hefei 230031
5. Institute of Intelligent Machines , Hefei Institutes of Physical Science , Chinese Academy of Sciences , Hefei 230031
- Publication Type:Journal Article
- Keywords:
copper-gadolinium;
nanomaterials;
nuclear shell structure;
antibacterial;
E. coli;
L929 cells
- From:
Acta Universitatis Medicinalis Anhui
2024;59(12):2157-2162
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the biocompatibility of copper-gadolinium nanomaterials and their antibacterial efficacy againstEscherichia coli(E.coli).
Methods:Copper-gadolinium nanomaterials were prepared using a hydrothermal method, and the samples were characterized and analyzed using instruments such as transmission electron microscopy. The biocompatibility of copper-gadolinium nanomaterials was evaluated through CCK-8 experiments with mouse fibroblast cells(L929). Copper-gadolinium nanomaterials were co-cultured withE.coli, and their antibacterial performance was observed and assessed.
Results:Transmission electron microscopy and Fourier transform infrared spectroscopy analysis confirmed the synthesis of the copper-gadolinium nanomaterials. The CCK-8 experiment results showed that the material had reliable biocompatibility within a concentration range of 0-2 μg/ml. The antibacterial experiments verified the excellent anti-E.coliactivity of copper-gadolinium, with the antibacterial effect positively correlating with concentration and co-cultivation time. When copper-gadolinium nanomaterials at a concentration of 2 μg/ml were co-cultured withE.colifor 4 hours, the antibacterial rate reached 99.99%.
Conclusion:The 2 μg/ml copper-gadolinium nanomaterials exhibit reliable biocompatibility and excellent anti-E.colicapabilities.
- Full text:2025022716100438988铜钆纳米材料对大肠埃希菌的抗菌性能研究_李青.pdf
