Research Progress on the Mechanism of Cerium Oxide Nanoparticles Against Anthracyclines Myocardial Injury
- VernacularTitle:纳米氧化铈抗蒽环类药物心肌损伤作用机制研究进展
- Author:
MENG Yingyue
1
;
HAN Xuanmao
2
;
LIN Xuefeng
2
Author Information
- Publication Type:Journal Article
- Keywords: anthracyclines; myocardial damage; cerium oxide nanoparticles
- From: Chinese Journal of Modern Applied Pharmacy 2023;40(15):2161-2166
- CountryChina
- Language:Chinese
- Abstract: Dose-dependent cardiotoxicity of anthracyclines limits its further use in cancer therapy. Recent animal studies have shown that cerium oxide nanoparticles in conjunction with anthracyclines can improve the efficacy of chemotherapy without increasing the damage to normal heart cells. This article introduces the biomedical properties of cerium oxide nanoparticles and the related mechanisms of cardiotoxicity of anthracyclines, and reviews the anti-oxidative stress and anti-apoptosis effects of cerium oxide nanoparticles in the cardiotoxicity of anthracyclines, so as to provide a possible strategy for clinical prevention and treatment of anthracyclines cardiotoxicity.
