Influencing factors and nomogram prediction model of pregnancy outcome of patients with vaginal bleeding after IVF/ICSI-ET
10.19405/j.cnki.issn1000-1492.2022.07.030
- Author:
Damin Zhu
1
,
2
,
3
,
4
,
5
;
Huijuan Zou
6
,
7
,
8
,
9
;
Jing Wang
6
,
7
,
8
,
9
;
Cong Ma
6
,
7
,
8
,
9
;
Xiaoqing Peng
6
,
7
,
8
,
9
;
Danyang Li
6
,
7
,
8
,
9
;
Yangfan Zhou
6
,
7
,
8
,
9
;
Yulu Yang
6
,
7
,
8
,
9
;
Yunxia Cao
6
,
7
,
8
,
9
;
Xiaofeng Xu
1
,
2
,
3
,
4
,
5
Author Information
1. Dept of Obstetrics and Gynecology，Chaohu Hospital of Anhui Medical University，Chaohu 238001
2. Dept of Obstetrics and Gynecology，The First Affiliated Hospital of Anhui Medical University，Hefei 230022
3. NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract，Anhui Medical University，Hefei 230032
4. Key Laboratory of Population Health Across Life Cycle，Anhui Medical University， Ministry of Education of thePeople&rsquo
5. s Republic of China，Hefei 230032
6. Dept of Obstetrics and Gynecology，The First Affiliated Hospital of Anhui Medical University，Hefei 230022
7. Anhui Province Key Laboratory of Reproductive Health and Genetics，Hefei，230032
8. Biopreservation and Artificial Organs，Anhui Provincial Engineering Research Center，Anhui Medical University，Hefei 230032
9. Anhui Provincial Institute of Translational Medicine，Hefei 230032
- Publication Type:Journal Article
- Keywords:
nomogram model;
embryo-transfer;
threatened abortion;
the onset of vaginal bleeding time;
human chorionic gonadotrophin
- From:
Acta Universitatis Medicinalis Anhui
2022;57(7):1171-1176
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the risk factors affecting the occurrence of complications in patients with vaginal bleeding after in vitro fertilization/intracytoplasmic sperm injection embryo transfer(IVF/ICSI-ET) and the construction of nomogram prediction model.
Methods:A total of 272 patients with threatened abortion after IVF/ICSI-ET were retrospectively analyzed in this study. They were divided into the live birth group and abortion group according to the final outcome of pregnancy. Patient characteristics were evaluated using the chi-square test, independent-samples Student's t-test or Wilcoxon rank sum test. A nomogram was created to predict the pregnancy outcome of women with threatened abortion who received IVF/ICSI using multivariate logistic regression coefficients.
Results:There was no significant difference in the basic data, percentage of frozen embryos, treatment method, number of embryos transferred, high-quality embryo rate, and embryo implantation rate of the live birth group and abortion group(P>0.05). There were significant differences in body mass index, the onset of vaginal bleeding time after transplantation, serum levels of hCG and progesterone on 14 th day after embryo-transfer, and the number of gestational sacs between the two groups(P<0.05). After multivariate logistic regression analysis, the onset of vaginal bleeding time after transplantation and serum hCG levels on 14 th day after transfer were statistically significant(P<0.05). The nomogram was established based on the above indicators, with an area under the curve of 0.710 for the nomogram. The area under the ROC curve of our nomogram was better than the area under the ROC curve of a single risk factor(AUC of bleeding time after embryo-transfer: 0.644, AUC of serum hCG14:0.625).
Conclusion:The nomogram model established based on the onset of vaginal bleeding time after embryo-transfer and serum hCG value on 14 th day after embryo-transfer can better predict pregnancy outcome of patients with threatened abortion after IVF/ICSI-ET.
- Full text:2025022710425883865IVF_ICSI-ET后阴...分析及其列线图预测模型构建_朱大敏.pdf
