Study of the risk of lymph node metastasis in early gastric cancer and its correlation with HER2 status
10.19405/j.cnki.issn1000-1492.2022.07.026
- Author:
Zhen Zhu
1
;
Pengyue Zhang
1
;
Yongping Cai
2
;
Yeqin Yang
1
;
Jingjing Wang
2
;
Yalei Wang
1
Author Information
1. Dept of Gastroenterology，The First Affiliated Hospital of Anhui Medical University，Hefei 230022
2. Dept of Pathology，The First Affiliated Hospital of Anhui Medical University，Hefei 230022
- Publication Type:Journal Article
- Keywords:
early gastric cancer;
HER2;
clinicopathologic features;
lymph node metastasis;
risk prediction
- From:
Acta Universitatis Medicinalis Anhui
2022;57(7):1151-1155
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between clinicopathologic features like human epidermal growth factor receptor type 2(HER2) status and lymph node metastasis, meanwhile, to establish a prediction model for the risk of lymph node metastasis in early gastric cancer.
Methods:Multiple data of 157 patients who underwent early gastric cancer radical gastrectomy were involved and analyzed. Further, the risk prediction model was established for lymph node metastasis of early gastric cancer.
Results:Among these 157 patients, 31 cases were reported lymph node metastasis, with a rate of 19.7%. Analysis showed that female patients, HER2 IHC(3+), infiltrating into submucosa, poor degree of differentiation and vascular invasion accounted for a large proportion in lymph node metastasis(P<0.05). Analysis also showed that HER2 IHC(3+), infiltrating into submucosa, poor degree of differentiation and vascular invasion were independent risk factors for lymph node metastasis in early gastric cancer(P<0.05). According to the above analysis results, the prediction models for lymph node metastasis risk of early gastric cancer were established respectively included or excluded HER2 status, and the area under the ROC curve(AUC) was 0.800 and 0.759, respectively. Meanwhile, differentiated tumor accounted for a large proportion in HER2 IHC(3+)(P<0.05).
Conclusion:HER2 IHC(3+), infiltrating into submucosa, poor degree of differentiation and vascular invasion were independent risk factors of lymph node metastasis in early gastric cancer. The new established model including HER2 status has good sensitivity and specificity, which may provide a reference for predicting the risk of lymph node metastasis in early gastric cancer.
- Full text:2025022710182110279早期胃癌淋巴结转移风险及其与HER2状态的相关性_朱振.pdf
