Research progress on NLRP3 inflammasome-mediated regulation of tissue remodeling during orthodontic tooth movement
10.12016/j.issn.2096-1456.202440017
- Author:
WANG Jiajia
1
;
ZHANG Jiangtao
1
;
ZENG Fulei
1
Author Information
1. Affiliated Stomatological Hospital of Zunyi Medical University
- Publication Type:Review
- Keywords:
NLRP3 inflammasome / orthodontic tooth movement / interleukin-1β / interleukin-18 / pyroptosis / alveolar bone / periodontitis / root resorption
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2025;33(2):169-176
- CountryChina
- Language:Chinese
-
Abstract:
NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome mediates inflammation, induces pyroptosis, and regulates periodontal tissue remodeling through the maturation and secretion of its downstream cysteine protease 1 (Caspase-1)-dependent pro-inflammatory cytokines, interleukin (IL)-1β and IL-18. Orthodontic force mediates the aseptic inflammation of periodontal tissues and triggers adaptive alteration of periodontal tissues, thereby promoting the movement and stability of orthodontic teeth. NLRP3 inflammasome plays an important role in orthodontic tooth movement and causes periodontal tissue inflammation and orthodontic inflammatory root resorption in orthodontic patients. Literature review suggests that NLRP3 inflammasome is involved in the activation and differentiation of periodontal ligament fibroblasts, periodontal ligament stem cells, macrophages, osteoblasts, and osteoclasts in orthodontic tooth mobile tissue remodeling. Additionally, it targets the upstream nuclear factor kappa-B signaling pathway; downstream effectors, such as Caspase-1, IL-1β, and IL-18; and the NLRP3 inflammasome components for regulating tooth movement as well as treating and preventing orthodontics-associated periodontitis and orthodontic-induced inflammatory root resorption. Future studies can be focused on the specific mechanism of NLRP3 inflammasome tissue modification during orthodontic tooth movement. This article reviews the effects and regulatory mechanisms of the NLRP3 inflammasome signaling pathway on the corresponding tissue remodeling during orthodontic tooth movement.
- Full text:2025022709531330075NLRP3炎症小体调节正畸牙移动过程中组织改建的研究进展.pdf
