Study of intestinal bacterial overgrowth in patients with chronic liver disease
10.19405/j.cnki.issn1000-1492.2022.07.022
- Author:
Mengxue Huang
1
;
Gang Chen
1
;
Peng Wang
2
;
Shiguo Cao
1
;
Jianming Xu
1
;
Qiao Mei
1
;
Rutao Hong
1
;
Weiping Zhang
1
Author Information
1. Dept of Gastroenterology，The First Affiliated Hospital of Anhui Medical University，Hefei 230022
2. Basic Medical College，Anhui Medical University，Hefei 230032
- Publication Type:Journal Article
- Keywords:
cirrhosis;
small intestinal bacterial overgrowth;
breath test;
oxidative stress;
gut microbiota
- From:
Acta Universitatis Medicinalis Anhui
2022;57(7):1134-1137
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To detect the difference in the incidence of small intestinal bacterial overgrowth(SIBO) in patients with liver cirrhosis and chronic hepatitis fibrosis(CHF) with the lactulose hydrogen breath test(LHBT), and to explore the relationship between SIBO and inflammatory factors and oxidative stress related indicators.
Methods:LHBT was performed on 38 CHF patients, 60 cirrhosis patients and 31 healthy controls to evaluate the incidence of SIBO. The patients were further divided into SIBO-positive and negative group. Then we compared related clinical symptoms and laboratory tests between the two groups and detected lipopolysaccharide(LPS), interleukin(IL)-6, tumor necrosis factor(TNF)-α, IL-10 level, and several kinds of oxidative stress indicators such as diamine oxidase(DAO), superoxide dismutase(SOD), glutathione(GSH), catalase(CAT). Statistical analysis was conducted to analyze the correlation between the concentration of LPS, IL-6, TNF-α, DAO, SOD, GSH, CAT and LHBT summation value.
Results:(1) The positive rate of SIBO in CHF group, cirrhosis group and control group was 36.84%, 60.00% and 9.68%, respectively. The difference was statistically significant(P<0.01).(2) The differences in CTP classification and ascites were statistically significant between the two subgroups with and without SIBO(P<0.05).(3) The levels of LPS, IL-6, CAT, DAO and SOD in SIBO-positive group were higher than those in negative group(P<0.05). However, the concentrations of IL-10, TNF-α and GSH were similar between the two groups.(4) The LHBT summation value was positively correlated with the concentrations of LPS, IL-6, DAO, SOD and CAT in serum(P<0.05), but had no significant correlation with TNF-α, IL-10 and GSH.
Conclusion:Compared with healthy controls, CHF and cirrhosis patients are more likely to develop SIBO. It is also related to the increase of inflammatory factors and oxidative stress indexes in peripheral blood. SIBO may aggravate the inflammatory response of CHF and cirrhosis patients through intestinal flora dysregulation and oxidative stress, thus aggravating the disease change.
- Full text:2025022709445794297慢性肝病患者中小肠细菌过度生长的研究_黄梦雪.pdf
