Expression and clinical analysed of serum HSP90α and cancer tissue gene HSP90AA1 in the diagnosis and prognosis of lung cancer
10.19405/j.cnki.issn1000-1492.2022.07.005
- Author:
Xiaoyu Dong
1
;
Tao Zhong
2
;
Yuanzi Ye
3
;
Meijuan Zheng
4
;
Jilong Shen
5
Author Information
1. Dept of Clinical Laboratory，Chaohu Hospital of Anhui Medical University，Chaohu 238000
2. Dept of Blood Transfusion，The First Affiliated Hospital of Anhui Medical University，Hefei 230022
3. Dept of Pathology，The First Affiliated Hospital of Anhui Medical University，Hefei 230022
4. Dept of Clinical Laboratory ,The First Affiliated Hospital of Anhui Medical University，Hefei 230022
5. Dept of Microbiology and Parasitology，Anhui Medical University， the Key Laboratory of Pathogen Biology Anhui，Heifei 230032
- Publication Type:Journal Article
- Keywords:
lung cancer;
heat shock protein 90a;
HSP90AA1;
lung adenocarcinoma;
lung squamous cell carcinoma
- From:
Acta Universitatis Medicinalis Anhui
2022;57(7):1034-1040
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the high expression level of serum heat shock protein 90α(HSP90α) and gene HSP90 AA1 in cancer tissue, and to discover the prognosis of lung cancer.
Methods:A total of 109 cases of lung cancer were collected as the experimental group; 38 lung inflammation groups as the reference group; and 30 healthy controls. The serum HSP90α levels between the three groups were compared; the correlation between HSP90α and clinical parameters were analyzed. The TCGA data were used to analyze the correlation between the expression level of HSP90 AA1 and various pathological features, as well as its influence on the prognosis of lung cancers.
Results:The serum HSP90α concentrations in the experimental group were higher than those of the reference group and the control group(P<0.05). The ROC curve area of HSP90α in the diagnosis of lung cancer was 0.898(P<0.05); the expression of HSP90α in the lung squamous cell carcinoma group(LUSC) and the small cell lung cancer group(SCLC) were higher than those in lung adenocarcinoma group(LUAD)(P<0.05); the level of HSP90α decreased when condition alleviated, while increased significantly when disease progressed(P<0.05); Further TCGA database showed that the expression of HSP90 AA1 in cancer tissues was higher than that of adjacent cancer tissues(P<0.05),meanwhile, remarkably increased in LUSC compared with in LUAD(P<0.05). The expression of HSP90 AA1 has no significant correlation with the age, gender, clinical stage, and tumor residue of lung cancer patients. Survival analysis and Cox regression analysis showed that high expression of HSP90 AA1 reduced the overall survival(OS) of lung cancer patients; HSP90 AA1 was an independent prognostic factor for lung cancer patients.
Conclusion:Serum HSP90α and HSPAA1 in cancer tissues are elevated in patients with lung cancer, which should be used as an auxiliary diagnosis method for lung cancer. Meanwhile they should be used for therapeutic effect observation and survival status prediction.
- Full text:2025022616484113068血清HSP90α和癌组织基...在肺癌中的高表达及预后价值_董晓玉.pdf
