Preliminary study on the changes of cerebral blood flow in patients with type 2 diabetes mellitus by arterial spin labeling
10.19405/j.cnki.issn1000-1492.2022.06.030
- Author:
Wei Luo
1
;
Jie Wang
2
;
Mimi Chen
2
;
Fujun Liu
2
;
Shanlei Zhou
3
;
Datong Deng
3
;
Jiajia Zhu
2
;
Yongqiang Yu
1
,
2
Author Information
1. Dept of Imaging,Chaohu Hospital of Anhui Medical University, Hefei 238000
2. Dept of Radiology,The First Afiliated Hospital of Anhui Medical Uniersity,Heei 230022
3. Dept of Endocrinology, The First Afiliated Hospital of Anhui Medical Uniersity,Heei 230022
- Publication Type:Journal Article
- Keywords:
arterial spin labeling;
type 2 diabetes mellitus;
cerebral blood flow: olfactory dysfunction: cognitive function
- From:
Acta Universitatis Medicinalis Anhui
2022;57(6):1002-1005
- CountryChina
- Language:Chinese
-
Abstract:
Abstract:To investigate the changes of cerebral blood flow(CBF) in patients with type 2 diabetes mellitus(T2 DM) and its correlation with cognitive function and olfactory impairment.
Methods:Cognitive function assessment and smell identification test were performed on 83 patients with T2 DM and 62 healthy controls(HC). Three-dimensional pseudo-continuous arterial spin labeling(3 D-pcASL) head images were collected from the two groups. CBF values of the cerebral cortex were compared between the patients and HC after the postprocessing. Correlations between the CBF values and cognitive function assessment and between the CBF values and smell identification test scores were analyzed as well.
Results:Compared to the HC, Chinese smell identification test(CSIT), montreal cognitive assessment(MoCA), digit span test(DST), verbal fluency test(VFT) scores were lower in T2 DM patients(P<0.05).The CBF of the bilateral middle frontal gyrus in T2 DM patients was higher than that in HC group(P<0.001). The CBF of the bilateral gyrus rectus and olfactory cortex in T2 DM patients was lower than that in HC group(P<0.001).
Conclusion:The cognitive and olfactory function of patients with T2 DM decreased. Patients with T2 DM have abnormal perfusion in the bilateral middle frontal gyrus, gyrus rectus and olfactory cortex, revealing that CBF changes in these brain regions may be one of the causes for cognitive impairment and olfactory dysfunction in T2 DM.
- Full text:2025022610153422312动脉自旋标记技术对2型糖尿...患者脑血流量改变的初步研究_罗维.pdf
