Study on the correlation between inflammatory indicators in the hyperacute phase of acute ischemic stroke and early neurological deterioration, syndrome factors, and prognosis
10.3969/j.issn.1006-2157.2025.01.012
- VernacularTitle:急性缺血性中风超急性期炎性指标与早期神经功能恶化、证候要素及预后的相关性研究
- Author:
Ligaoge KANG
1
,
2
;
Ying GAO
3
;
Jinyue BAI
2
;
Huan TANG
2
;
Hongbo SHEN
2
;
Lei LIU
2
;
Lingbo KONG
4
Author Information
1. Beijing University of Chinese Medicine
2. Fangshan Hospital, Beijing University of Chinese Medicine
3. Institute of Encephalopathy, Beijing University of Chinese Medicine
4. Dongzhimen Hospital, Beijing University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
acute ischemic stroke;
traditional Chinese medicine syndromes;
early neurological deterioration;
hyperacute phase;
interleukin;
tumor necrosis factor-α;
vascular endothelial growth factor;
intercellular adhesion molecule-1
- From:
Journal of Beijing University of Traditional Chinese Medicine
2025;48(1):98-107
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Inflammatory cascade reactions play a crucial role in secondary neuronal injury in acute ischemic stroke (AIS). The aim of this study was to explore the correlations between specific serological indicators, early neurological deterioration (END), disease prognosis, and syndrome factors in AIS based on this injury mechanism.
Methods:The data for this study were collected from 135 patients with AIS admitted to the emergency department of Fangshan Hospital, Beijing University of Chinese Medicine, within 24 h of onset between November 2019 and May 2021. Among these, 29 patients had complete data and experienced END. Additionally, 9 non-END patients were matched from the remaining 90 patients with complete data, resulting in a total of 38 patients for statistical analysis. Statistical methods, including logistic regression and receiver operating curves, were used to analyze the correlation between serum levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-10 (IL-10), vascular endothelial growth factor (VEGF), and intercellular adhesion molecule-1 (ICAM-1) within 24 h of END onset, disease prognosis, and syndrome factors. Grouping criteria included END occurrence, presence of syndrome elements on the first and third day post-onset, and prognosis at 90 days post-onset.
Results:All 38 cases had onset time of less than 12 h, and there were no significant differences in age, gender, and onset time between the END and non-END groups. The TNF-α serum level within 24 h of onset was not associated with the occurrence of END but was negatively correlated with all-cause mortality at 90 days [0.110; P<0.05). An elevated IL-10 serum level within 24 h of onset showed a strong negative correlation with non-disabling and good functional outcomes at 90 days post-onset (0.110; P<0.05). When the ICAM-1 serum levels exceeded 233 599.500 μg/L and 125 141.500 μg/L, respectively, the susceptibility to endogenous wind and endogenous fire on the third day of onset was 15.364 times and 6.071 times higher, respectively, than that in patients with serum levels below these thresholds.
Conclusion:As accessible and objective biomarkers, inflammatory serum indicators are closely associated with both disease progression and traditional Chinese medicine (TCM) syndrome elements. They enhance AIS diagnosis, assessment, and treatment and contribute to a deeper understanding of the role of TCM syndrome differentiation in AIS diagnosis and treatment.
- Full text:2025022609365642831Study on the correlation between inflammatory indicators in the hyperacute phase of acute ischemic stroke and early neurological deterioration, syndrome factors, and prognosis.pdf
