Rape Pollen Promote Androgenic Alopecia Mice by Increasing bFGF and VEGF Levels
10.13748/j.cnki.issn1007-7693.20222939
- VernacularTitle:油菜花粉通过提高bFGF和VEGF水平改善小鼠雄激素源性脱发
- Author:
PAN Hongye
1
,
2
,
3
;
ZHU Feng
1
,
4
;
YU Jiayu
1
,
4
;
GU Yueting
3
;
HU Weitong
3
;
HE Houhong
1
,
4
;
YAO Jianbiao
1
,
4
;
GAO Jianqing
3
;
HU Jiangning
1
,
4
Author Information
1. Zhejiang CONBA Pharmaceutical Co., Ltd., Hangzhou 310052, China
2. Zhejiang Provincial Key Laboratory of Traditional Chinese Medicine Pharmaceutical Technology, Hangzhou 310052, China
3. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
4. Zhejiang Provincial Key Laboratory of Traditional Chinese Medicine Pharmaceutical Technology, Hangzhou 310052, China
- Publication Type:Journal Article
- Keywords:
rape pollen;
androgenetic alopecia;
hair regeneration;
angiogenesis
- From:
Chinese Journal of Modern Applied Pharmacy
2023;40(16):2203-2209
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the improvement effect of rape pollen on androgenic alopecia mice and its mechanism. METHODS The blank group, model group, positive drug group and administration group were set up, the androgenic alopecia mice model was induced by applying 0.2% testosterone after hair removal. The hair growth rate of mice were observed by using 5% minoxidil as positive drug and 0.4 g·mL-1 rape pollen oil solution as administration group. The hair quality and follicle condition of mice were observed by scanning electron microscope(SEM) and HE staining of skin tissue, respectively. The level of VEGF and bFGF in skin were detected by immunofluorescence staining and Western blotting, while the level of serum sex hormones and reactive oxygen species were detected by ELISA. RESULTS Rape pollen could significantly promote the hair growth in mice and improve the state of mice hair scales compared with model group. Mechanism exploration experiments showed that rape pollen could not promote hair regeneration of mice by regulating hormone levels or anti-oxidative stress. However, rape pollen could increase the expression of bFGF and VEGF related to skin angiogenesis at the modeling site. CONCLUSION Rape pollen can promote hair regeneration in androgenic alopecia mice. Its mechanism may be that it promotes perifollicular vascular regeneration by increasing bFGF and VEGF level.
