Extraction process optimization and quality control of Xuetong capsules
10.12206/j.issn.2097-2024.202409003
- VernacularTitle:血通胶囊提取工艺优化及质量控制研究
- Author:
Fangjian CHEN
1
,
2
;
Juanjuan ZHAO
3
;
Kanti YE
3
;
Yuxin SUN
4
;
Jiyong LIU
5
,
6
;
Jun YANG
3
Author Information
1. Department of Pharmacy, Geriatric Nursing Hospital of Huangpu District, Shanghai 200010, China
2. School of Pharmacy, Shandong University of Traditional Chinese Medicine, Pharmacy Department, Jinan 250399, China.
3. Department of Pharmacy, Xiangshan Hospital of Traditional Chinese Medicine, Shanghai 200020, China.
4. Department of Pharmacy, Yuyuan Sub-district Community Health Service Center of Huangpu District, Shanghai 200010, China.
5. School of Pharmacy, Shandong University of Traditional Chinese Medicine, Pharmacy Department, Jinan 250399, China
6. Department of Pharmacy, Fudan University Affiliated Cancer Hospital, Shanghai 200032, China.
- Publication Type:Originalarticles
- Keywords:
Xuetong Capsule;
Orthogonal experiment;
Extraction process optimization;
High performance liquid chromatography method;
Content determination
- From:
Journal of Pharmaceutical Practice and Service
2025;43(2):82-86
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the extraction process of Xuetong capsules and establish its quality control method. Methods The extraction process was optimized by orthogonal experiment using ethanol reflux method to investigate the effects of different factors on diphenylstilbene, aloin and extraction yield. The content of 5 anthraquinone compounds in Xuetong capsule was determined by HPLC. Results The optimal extraction process was to add 10 times ethanol, with an ethanol concentration of 70%, and extract 3 times, each time for 1 h; 5 components had a good linear relationship with peak area within a certain concentration range, r>0.999 7; The range of sample recovery rate was 93.66%-96.85%, RSD range of 1.48%-1.66%. The content determination results of the 5 components in three batches of Xuetong capsules were （0.632-0.641）, （0.660-0.681）, （1.968-1.991）, （2.547-2.580）, and （1.076-1.101） mg/g. Conclusion The method was accurate, reproducible, and highly feasible, which could be references for producing and improving the quality control standards of Xuetong capsules.
