Evaluation of Hepatic Hemangioma by Tc-99m Red Blood Cell Hepatic Blood Pool Scan.
- Author:
Myung Hee SOHN
1
Author Information
1. Department of Nuclear Medicine, Institute for Medical Sciences, and Research Institute of Clinical Medicine, Chonbuk National University Medical School, Chonju, Korea. mhsohn@chonbuk.ac.kr
- Publication Type:Review
- Keywords:
Hepatic hemangioma;
Tc-99m RBC;
blood pool scan;
SPECT;
false-positive;
false-negative
- MeSH:
Adenoma;
Carcinoma, Hepatocellular;
Carcinoma, Small Cell;
Colon;
Diagnosis;
Erythrocytes*;
Gamma Cameras;
Hemangioma*;
Hemangiosarcoma;
Liver;
Lung;
Perfusion;
Prevalence;
Radioactivity;
Tomography, Emission-Computed, Single-Photon
- From:Korean Journal of Nuclear Medicine
2005;39(3):151-162
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Hemangioma is the most common benign tumor of the liver, with a prevalence estimated as high as 7%. Tc-99m red blood cell (RBC) hepatic blood pool scan with single photon emission computed tomography (SPECT) imaging is extremely useful for the confirmation or exclusion of hepatic hemangiomas. The classic finding of absent or decreased perfusion and increased blood pooling ("perfusion/blood pool mismatch") is the key diagnostic element in the diagnosis of hemangiomas. The combination of early arterial flow and delayed blood pooling ("perfusion/blood pool match") is shown uncommonly. In giant hemangioma, filling with radioactivity appears first in the periphery, with progressive central fill-in on sequential RBC blood pool scan. However, the reverse filling pattern, which begins first in the center with progressive peripheral filling, is also rarely seen. Studies with false-positive blood pooling have been reported infrequently in nonhemangiomas, including hemangiosarcoma, hepatocellular carcinoma, hepatic adenoma, and metastatic carcinomas (adenocarcinoma of the colon, small cell carcinoma of the lung, neruroendocrine carcinoma). False-negative results have been also reported rarely except for small hemagniomas that are below the limits of spatial resolution of gamma camera.
