Study on Pharmacokinetics and Pharmacodynamics of Oral Colon Targeted pH-Sensitive Hydrogel of Hydrocortisone Sodium Succinate
10.13748/j.cnki.issn1007-7693.20223138
- VernacularTitle:氢化可的松琥珀酸钠口服结肠靶向pH敏感型水凝胶的药动学与药效学研究
- Author:
YOU Cuiyu
1
,
2
,
3
;
SHI Rui
4
;
SUN Jinyao
1
,
2
,
3
;
DENG Xiang
1
,
2
,
3
;
WANG Xidan
1
,
2
,
3
;
DENG Wenting
1
,
2
,
3
;
ZHANG Wenjuan
1
,
2
,
3
Author Information
1. Department of Pharmacy, The First Affiliated Hospital of Xi'
2. an Jiaotong University, Xi'
3. an 710061, China
4. Department of Pharmacy, Yuncheng Central Hospital, Yuncheng 044000, China
- Publication Type:Journal Article
- Keywords:
hydrocortisone sodium succinate;
pH-sensitive;
oral colon-specific drug delivery system;
plasma concentration;
pharmacodynamics
- From:
Chinese Journal of Modern Applied Pharmacy
2023;40(17):2427-2434
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To study the pharmacokinetics and pharmacodynamics of oral colon targeted pH-sensitive hydrogel of hydrocortisone sodium succinate(HSS-GEL). METHODS The plasma concentration changes of HSS-GEL and HSS in the mice were investigated; 2, 4, 6-trinitrobenzene sulfonic acid(TNBS)-induced mouse model of ulcerative colitis(UC) was established, disease activity index(DAI), colon length, myeloperoxidase(MPO) and organ index were used as indicators to investigate the therapeutic effect of HSS-GEL on colitis. RESULTS The results showed that the Tmax, Cmax and AUC of HSS-GEL were significantly different from those of HSS(P<0.01). The Tmax of HSS-GEL was significantly longer than that of HSS, and the time of drug absorption into the blood was significantly delayed. The Cmax of HSS-GEL group was significantly lower than that of HSS. The AUC of the HSS-GEL group was 39.38% of the same dose of HSS, indicating that the amount of the drug absorbed into blood was significantly reduced after the HSS was made into HSS-GEL orally. After modeling, DAI, MPO activity and organ index were increased, while the colon was shortened due to the inflammatory reaction, with the treatment of HSS-GEL, DAI, MPO activity and some organ index of mice were significantly decreased comparing with TNBS group(P<0.05 or P<0.01). The degree of reduction of MPO activity and some organ indexes of the mice in the TNBS+HSS-GEL group were significantly greater than those in the TNBS+HSS group, indicating that HSS-GEL had good therapeutic effect on TNBS-induced ulcerative colitis, and the effect was better than that of HSS. CONCLUSION The HSS-GEL prepared has good colon targeting characteristic and colitis treatment effect.
